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Sickle Cell Anemia

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Sickle Cell Anemia

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  1. Sickle Cell Anemia 1) Single nucleotide substitution (“point mutation”) in the genefor the beta chain of hemoglobin. 2) Different amino acid gets placed in the peptide chain.. 3) Beta chain synthesized from the sickle-cell allele does not“fold” correctly and hempglobin molecules “clump” togetherforming a red blood cell that resembles a sickle. 4) Sickled cells die early (10-20 days vs. 120 days) producing anemia. 5) Sickled cells clog the fine capillaries, leading to lack of oxygen intarget organs.

  2. http://bio.winona.msus.edu/berg/308s04/Lec-note/19-new.htm

  3. Hemoglobin molecules “clump” Sickle-shape red blood cells Rapid breakdownof sickled cells Impededcirculation Organdamage Overactivebone marrow Anemia Skeletalproblems Impaireddevelopment Infectionrisk Pain Fatigue

  4. http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=gnd.section.98http://www.ncbi.nlm.nih.gov/books/bv.fcgi?call=bv.View..ShowSection&rid=gnd.section.98

  5. http://peptide.ncsa.uiuc.edu/tutorials_current/Sickle_Cell_Anemia/SC2001/intro.htmlhttp://peptide.ncsa.uiuc.edu/tutorials_current/Sickle_Cell_Anemia/SC2001/intro.html

  6. http://www.blackwellpublishing.com/ridley/images/sickle_cell_anaemia.jpghttp://www.blackwellpublishing.com/ridley/images/sickle_cell_anaemia.jpg

  7. Why is SCA so common in some areas? http://anthro.palomar.edu/synthetic/synth_7.htm

  8. http://anthro.palomar.edu/synthetic/synth_7.htm

  9. Different origins (independent mutations) of the SCD allele