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Seattle Longitudinal Study: Midlife Cognitive Change and Neural Functioning in Aging Adults

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  1. Seattle Longitudinal Study K. Warner Schaie & Sherry Willis (PIs) Collaborators: Elizabeth Aylward Paul Borghesani Kurt Weaver Tara Madhyastha Funding: NIA (R37 AG024102

  2. Seattle Longitudinal Study:A Cohort-Longitudinal Study of Adult Cognition

  3. Midlife Study: Impact of Midlife Cognitive Change on Neural & Cognitive Functioning in Old Age

  4. Midlife Change in Memory Midlife Individual Differences Midlife Normative Change

  5. * Disease * Biomarkers * Lifestyle Risk *Shrinkage (MRI) *White Matter Integrity (DTI) *Cortical Thinning Risk Factors Structural Neural Changes Cognitive Change Decline Gain Stable Abilities: Memory Executive Speed Midlife Cognition Old Age Cognition Functional Neural Changes Resource Factors Default Network Activity • Cognitive Engage • Exercise • Personality

  6. Hippocampal Volume: Midlife Memory Status & Age at Scan

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