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Advanced Nanotissue Engineering: Integrating Nanotechnology with Cardiovascular and Neural Tissues

This overview presents cutting-edge research in nanotissue engineering, focusing on the intersection of cardiovascular and neural tissues, including blood vessels, cardiac myocyte differentiation, and the engineering of complex vascular grafts. Led by Dr. Peter I. Lelkes at Drexel University, the program explores the application of nanotechnology in tissue scaffolds, angio-genesis, and self-assembled structures. Innovations like electrospun nanofibers and carbon nanoparticle integration drive advances in creating functional constructs for regenerative medicine. Reach out for collaboration at pilelkes@drexel.edu.

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Advanced Nanotissue Engineering: Integrating Nanotechnology with Cardiovascular and Neural Tissues

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  1. Cardiovascular Tissues: • Blood Vessels • Heart • Neural Tissues: • Brain • Peripheral Nerves • Endocrine Tissues: • Pancreas • Adrenal • Tumor Spheroids: • Breast Cancer • Angiogenesis • MDR NANOTISSUE ENGINEERING RESEARCH P R O G R A M O V E R V I E W Cellular Tissue Engineering: Primary Target Tissues / Organs • Faculty:Peter I. Lelkes, PhD, Drexel University. • E-mail: pilelkes@drexel.edu

  2. Macro- / Micro-scale for Individual Components: • Cells Cell Aggregates. • Scaffolds: Fibrous, Textured. 50 nm • In vivo: NanoScale Cellular Action: • Cell-ECM communications are on the nano-scale. NANOTISSUE ENGINEERING RESEARCH P R O J E C T O V E R V I E W In vitro: Tissue Engineering • Faculty:Peter I. Lelkes, PhD, Drexel University. • E-mail: pilelkes@drexel.edu

  3. Conductivity: Carbon Nanoparticles • Cells: Cardiac Myocyte Precursors NANOTISSUE ENGINEERING RESEARCH P R O J E C T O V E R V I E W Induction of Myocyte Differentiation By Electrical Stimulation • Faculty:Peter I. Lelkes, PhD, P. Bidez, L. Venancio, Drexel University; A. MacDiarmid, PhD, University of Pennsylvania. • E-mail: pilelkes@drexel.edu

  4. Composition: • Substrate : polydimethylsiloxane (PDMS) (Sylgard® 184) • Self-assembled monolayer : 3-(triethoxysilyl)propylsuccinic anhydride (TESPSA) (carboxylic acid terminated); • Peptide: RGD Width = 18 m Depth = 500 nm Width = 3.3 m Depth = 100 nm • Texture: Smooth Coarse Fine PDMS TESPSA-PDMS RGD-PDMS NANOTISSUE ENGINEERING RESEARCH P R O J E C T O V E R V I E W Nanotechnology-based Elastomeric Vascular Graft • Faculty: Peter I. Lelkes, PhD, Drexel University; R. J. Composto, P. Uttayarat, PhD, University of .Pennsylvania; and S. Chaturvedi, Rohm and Haas. • E-mail: pilelkes@drexel.edu

  5. NANOTISSUE ENGINEERING RESEARCH P R O J E C T O V E R V I E W Electrospinning of Conducting Nanofibrous Scaffolds • Unique Features: • Use of electroactive, nanofibrous scaffolds for tissue engineering purposes. • Capability of generating oriented / aligned scaffolds. • Electrospinning of pure PANi nanofibers / scaffolds. • Co-electrospinning of natural ECM proteins (collagen) / biodegradable polymers. • Generation of novel electroactive scaffolds by co-electrospinning of PLA with carbon nanotubes. • Faculty: Peter I. Lelkes, PhD, F. Ko, PhD, Levy, Y. Wei, PhD, Drexel University; A. MacDiarmid, PhD, University of Pennsylvania. • E-mail: pilelkes@drexel.edu

  6. Porous foam (pore size equals ~ 10 nm). Nanofibrous matt (fiber diameter < 100 nm). NANOTISSUE ENGINEERING RESEARCH P R O J E C T O V E R V I E W Tissue Engineering of Fetal Mouse Lung Using Collagenous Scaffolds • Faculty: Peter I. Lelkes, PhD, Mondrinos, S. Koutzaki, PhD, V. Finck, PhD, F. Ko, PhD, Drexel University. • E-mail: pilelkes@drexel.edu

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