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NANOTISSUE ENGINEERING RESEARCH

Cardiovascular Tissues: Blood Vessels Heart. Neural Tissues: Brain Peripheral Nerves. Endocrine Tissues: Pancreas Adrenal . Tumor Spheroids: Breast Cancer Angiogenesis MDR. NANOTISSUE ENGINEERING RESEARCH. P R O G R A M O V E R V I E W.

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NANOTISSUE ENGINEERING RESEARCH

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  1. Cardiovascular Tissues: • Blood Vessels • Heart • Neural Tissues: • Brain • Peripheral Nerves • Endocrine Tissues: • Pancreas • Adrenal • Tumor Spheroids: • Breast Cancer • Angiogenesis • MDR NANOTISSUE ENGINEERING RESEARCH P R O G R A M O V E R V I E W Cellular Tissue Engineering: Primary Target Tissues / Organs • Faculty:Peter I. Lelkes, PhD, Drexel University. • E-mail: pilelkes@drexel.edu

  2. Macro- / Micro-scale for Individual Components: • Cells Cell Aggregates. • Scaffolds: Fibrous, Textured. 50 nm • In vivo: NanoScale Cellular Action: • Cell-ECM communications are on the nano-scale. NANOTISSUE ENGINEERING RESEARCH P R O J E C T O V E R V I E W In vitro: Tissue Engineering • Faculty:Peter I. Lelkes, PhD, Drexel University. • E-mail: pilelkes@drexel.edu

  3. Conductivity: Carbon Nanoparticles • Cells: Cardiac Myocyte Precursors NANOTISSUE ENGINEERING RESEARCH P R O J E C T O V E R V I E W Induction of Myocyte Differentiation By Electrical Stimulation • Faculty:Peter I. Lelkes, PhD, P. Bidez, L. Venancio, Drexel University; A. MacDiarmid, PhD, University of Pennsylvania. • E-mail: pilelkes@drexel.edu

  4. Composition: • Substrate : polydimethylsiloxane (PDMS) (Sylgard® 184) • Self-assembled monolayer : 3-(triethoxysilyl)propylsuccinic anhydride (TESPSA) (carboxylic acid terminated); • Peptide: RGD Width = 18 m Depth = 500 nm Width = 3.3 m Depth = 100 nm • Texture: Smooth Coarse Fine PDMS TESPSA-PDMS RGD-PDMS NANOTISSUE ENGINEERING RESEARCH P R O J E C T O V E R V I E W Nanotechnology-based Elastomeric Vascular Graft • Faculty: Peter I. Lelkes, PhD, Drexel University; R. J. Composto, P. Uttayarat, PhD, University of .Pennsylvania; and S. Chaturvedi, Rohm and Haas. • E-mail: pilelkes@drexel.edu

  5. NANOTISSUE ENGINEERING RESEARCH P R O J E C T O V E R V I E W Electrospinning of Conducting Nanofibrous Scaffolds • Unique Features: • Use of electroactive, nanofibrous scaffolds for tissue engineering purposes. • Capability of generating oriented / aligned scaffolds. • Electrospinning of pure PANi nanofibers / scaffolds. • Co-electrospinning of natural ECM proteins (collagen) / biodegradable polymers. • Generation of novel electroactive scaffolds by co-electrospinning of PLA with carbon nanotubes. • Faculty: Peter I. Lelkes, PhD, F. Ko, PhD, Levy, Y. Wei, PhD, Drexel University; A. MacDiarmid, PhD, University of Pennsylvania. • E-mail: pilelkes@drexel.edu

  6. Porous foam (pore size equals ~ 10 nm). Nanofibrous matt (fiber diameter < 100 nm). NANOTISSUE ENGINEERING RESEARCH P R O J E C T O V E R V I E W Tissue Engineering of Fetal Mouse Lung Using Collagenous Scaffolds • Faculty: Peter I. Lelkes, PhD, Mondrinos, S. Koutzaki, PhD, V. Finck, PhD, F. Ko, PhD, Drexel University. • E-mail: pilelkes@drexel.edu

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