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Association Between Induced Abortion and Breast Cancer: A Comprehensive Meta-Analysis

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This meta-analysis evaluates the correlation between induced abortion (IA) and breast cancer incidence, synthesizing data from multiple studies to assess the overall odds ratio (OR) and confidence intervals (CI). The analysis includes a total of 16 studies with an overall I-squared statistic indicating significant heterogeneity. It reports various adjusted ORs, underscoring variability across research findings. This comprehensive overview aims to inform healthcare professionals and policymakers regarding the potential links between reproductive health choices and cancer outcomes.

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Association Between Induced Abortion and Breast Cancer: A Comprehensive Meta-Analysis

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  1. Study % % ID OR (95% CI) Weight Weight IA Jian J (2000) 2.90 (1.90, 4.40) 2.90 (1.90, 4.40) 4.10 4.10 Sanderson M (2001) 0.90 (0.70, 1.20) 0.90 (0.70, 1.20) 11.43 11.43 Zhang XJ (2001) 2.90 (1.90, 4.40) 2.90 (1.90, 4.40) 4.10 4.10 Ye Z (2002) 1.06 (0.84, 1.33) 1.06 (0.84, 1.33) 11.46 11.46 Zhang ZB (2003) 0.94 (0.79, 1.11) 0.94 (0.79, 1.11) 11.96 11.96 Li XL (2006) 5.52 (3.24, 9.41) 5.52 (3.24, 9.41) 0.93 0.93 Lin J (2008) 2.38 (1.09, 5.20) 2.38 (1.09, 5.20) 1.92 1.92 Jiang AR (2012) 1.52 (1.21, 1.92) 1.52 (1.21, 1.92) 10.62 10.62 Summary (I-squared = 80.8%, p = 0.000) 1.40 (1.04, 1.75) 1.40 (1.04, 1.75) 56.51 56.51 IA+SA Li N (2006) 3.55 (2.35, 5.36) 3.55 (2.35, 5.36) 3.14 3.14 Gao J (2007) 1.40 (1.07, 1.82) 1.40 (1.07, 1.82) 10.45 10.45 Liu JY (2008) 1.75 (1.31, 2.32) 1.75 (1.31, 2.32) 9.30 9.30 Li M (2010) 1.75 (1.58, 1.95) 1.75 (1.58, 1.95) 11.83 11.83 Bai HY (2011) 1.47 (0.72, 1.85) 1.47 (0.72, 1.85) 8.76 8.76 Summary (I-squared = 56.6%, p = 0.056) 1.68 (1.38, 1.99) 1.68 (1.38, 1.99) 43.49 43.49 Overall (I-squared = 86.7%, p = 0.000) 1.59 (1.28, 1.90) 1.59 (1.28, 1.90) 100.00 100.00 NOTE: Weights are from random effects analysis Supplement 1 Forest plot of studies on the association between breast cancer and at least 1 induced abortion based on adjusted odds ratio 1 IA: induced abortion SA: spontaneous abortion Summary OR and 95% CI Single OR and 95% CI

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