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DA dendrite formation

DA dendrite formation. Dendrite guidance. Clock model: axonal and dendritic growth are internally regulated, depending on how to respond to guidance molecules. Robo3 over-expression in TTMn. Robo3 over-expression in both GF & TTMn. WT. GF, giant fiber interneuron

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DA dendrite formation

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  1. DA dendrite formation

  2. Dendrite guidance

  3. Clock model: axonal and dendritic growth are internally regulated, depending on how to respond to guidance molecules

  4. Robo3 over-expression in TTMn Robo3 over-expression in both GF & TTMn WT GF, giant fiber interneuron TTMn: tergotrochantral motor neuron

  5. Neuropil model: same guidance molecules for attracting (or including) axon and dendrite together for synapse TRENDS in Neurosciences Vol.27 No.4 April 2004

  6. Sensory organs Proneural genes + associated MD neurons achaete scute + associated MD neurons atonal solo-MD neurons amos

  7. ES MD/ mono-ES MD/ poly-ES ASC ASC ASC solo-MD CH MD/ CH ato ato amos ES CH amos MD Brewster and Bodmer, 1995

  8. Control of dendrite development Luo. et al. Trends Neuroscience (2003)

  9. DA Dendrite formation

  10. pros mutations causes routing defect Constitutive active CDC42 induce supernumerary primary dendrites that fail to extend dorsally and grow secondary dendrites WT CDC42

  11. Lateral branch defects: (A) WT, (B) reduced, (C) fail to extend, (E, F) over shrinking Increased density

  12. Sequotia (水杉), Zn finger protein

  13. No invasion into ablated region in dorsal region in third instar No repulsion in dorsal group

  14. Competition between two dorsal groups of contralateral dorsal groups

  15. Dorsal dendrite overextension in flamingo mutants

  16. Class II Class I

  17. Class III

  18. Tiling of dendrites within the same class of DA neurons Development (2002) Grueber et al

  19. Cell (2003) Grueber et al

  20. Dendrites of different classes overlap extensively Class I and IV Class III and IV

  21. Class IV tiling

  22. Differential Cut levels in four types of DA neurons

  23. cut mutant phenotypes in class III

  24. Class II Class I

  25. Class I Class II

  26. Class IV No effect on class III

  27. Dendrites over-branching and over-lapping phenotypes

  28. Defect in like-dendrite avoidance response WT fry

  29. Heteroneuronal tiling defect Fry Trc kinase tiling Rac branching

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