1 / 24

Hypersensitivity Reactions

Learn about hypersensitivity reactions, including Type I to Type IV, antibody mediated and T cell mediated diseases, effector mechanisms, and therapies. Explore conditions like Graves' disease, Myasthenia gravis, immune complex diseases, and clinical manifestations of contact dermatitis.

fatimaa
Télécharger la présentation

Hypersensitivity Reactions

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Hypersensitivity Reactions

  2. Injurious, patologic immune reactions causing tissue injury and disease Excessive or aberrant immune response to: Foreign antigens (non-self) - non-infectious (environmental) - infectious Self (autologous) antigens failure of self-tolerance (autoimmunity, autoimmune diseases)

  3. Types of Hypersensitivity Reactions Type I Type II Antibody mediated Type III T cell mediated Type IV

  4. Type II and type III (comparison)

  5. Type II (Antibody-mediated diseases) (Cytotoxic type) Type II hypersensitivity animation

  6. Effector mechanisms

  7. Effector mechanisms

  8. Effector mechanisms

  9. Effector mechanisms

  10. Graves disease

  11. Myasthenia gravis

  12. Antibody-mediated diseases

  13. Type III (immune complex-mediated diseases) Type III hypersensitivity animation

  14. Effector mechanisms

  15. Effector mechanisms

  16. Effector mechanisms

  17. Immune complex diseases

  18. Serum sickness

  19. Therapy • Reduction fo inflammation (corticosteroids) • Plasmapheresis (reduction of circulating antibodies and immune comoplexes) • Anti-CD20-antibodies(reduction of B cell number) • Inhibition of auto-antibody production (CD40L antagonists)

  20. Type IV (Delayed-Type Hypersensitivity - DTH) Type IV hypersensitivity animation

  21. Effector mechanisms

  22. T cell-mediated diseases

  23. Clinical manifestation of contact dermatitis

  24. Therapy • Reduction of inlammtaion (corticosteroids and TNF antagonists) • T cell response inhibition (cyclosporin) • Antagonists of costimulation

More Related