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Nam + H +

Poly (ADP-ribosyl)ation is an immediate, transient and costly post-translational modification of nuclear proteins induced by DNA damaging agents. Elongation : • distal • processive • bimolecular Branching/elongation : 2%. Nuclear protein (acceptor). +. ATP. b NAD. Damaging agents.

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Nam + H +

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  1. Poly (ADP-ribosyl)ation is an immediate, transient and costly post-translational modification of nuclear proteins induced by DNA damaging agents • Elongation : • • distal • • processive • • bimolecular • Branching/elongation : 2% Nuclear protein (acceptor) + ATP bNAD Damaging agents Nam A d e , X-rays Alkylating agents CisPt CPT11 Bleomycin Oxygen radicals : ONOO H2O2 R i b R i b O H P P PARP-1 A d e PARP-2 Nam+ H+ O H R i b R i b 1 ' ' ' P P H1, H2B Lamin B O Nuclear protein (acceptor) A d e A d e A d e C Glu Glu 2 ' ' 2 ' 1 ' ' Topo I,II RPA T-ag DNA pol a O H R i b R i b R i b R i b R i b R i b O Targets P P P P P P PARG DNA pol b XRCC-1

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