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What is LIGASE….?!

Segmentation Algorithm. What is LIGASE….?!. CSF. GM. WM. 25 weeks. term. 30 weeks. adult. WM non-uniformity Contrast Changes Brain Size Partial Voluming. GM. noise. WM. CSF. 37 weeks. GM. noise. WM. CSF. 30 weeks. ? ? ? ? ? ? ? ?. ? ? ? ? ?.

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What is LIGASE….?!

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  1. Segmentation Algorithm What is LIGASE….?!

  2. CSF GM WM 25 weeks term 30 weeks adult WM non-uniformity Contrast Changes Brain Size Partial Voluming

  3. GM noise WM CSF 37 weeks GM noise WM CSF 30 weeks

  4. ? ? ? ? ? ? ? ? ? ? ? ? ? Methods: Segmentation

  5. WM min WM mean WM max - (x- m)2 / 2 s2 P = Ae LIGASE GM WM CSF

  6. ? Difference Probability Gradient Difference Cutoff Gradient Cutoff LIGASE reference voxel (Rv) ? test voxel (Tv) For Tv calculate 1. Gradient 2. Intensity difference from Rv 3. WM Probability based on Intensity Use probability to set 1. Gradient cutoff value 2. Intensity difference cutoff value Based on Cutoff value allow Tv to be 1. segmented and left for free growth 2. segmented and labeled for restricted growth 3. not segmented Segmentation Decision

  7. GM WM CSF min max - (x- m)2 / 2 s2 P = Ae LIGASE WM mean WM min WM max mean

  8. LIGASE Decreasing values of WM min

  9. GM WM CSF noise GM / noise GM or WM WM / CSF CSF CSF WM GM LIGASE+

  10. noise unknown GM / CSF WM / CSF GM / WM GM / noise GM CSF WM Anatomy Initial Classification Final Classification

  11. LIGASEplus Anatomy LIGASE

  12. Fin

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