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Human Genome Project

Human Genome Project. Long completed; began 60 years ago Goal is to understand & control Supercomputers are key Bioinforamtics Information science Biology Medicine Genome mapping Drug – DNA matching Predictive-preventive. Genotyping. Still controversial – your DNA tells all

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Human Genome Project

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  1. Human Genome Project • Long completed; began 60 years ago • Goal is to understand & control • Supercomputers are key • Bioinforamtics • Information science • Biology • Medicine • Genome mapping • Drug – DNA matching • Predictive-preventive

  2. Genotyping • Still controversial – your DNA tells all • Genotyped people get best care • Single nucleotide polymorphisms (SNP) • 0.1% of total DNA • Only 20 main SNP classes • determines you and health characteristics. • SNP uses • Easier diagnosis – predicable problems • Better preventative medicine • “Customized” medicine; by SNP class

  3. Genotyping cont. The haplotypes in the human genome have been produced by the mechanisms of reproduction and record the history of our species. They are closely linked genetic markers in a chromosome inherited as a group

  4. Bioinforamtics • DNA decoded; Blue Gene unlocked code • 2005; 180 days to decode the 3.2 billion DNA letters • 2055; decode/profile in 8 minutes and affordable • Today, diagnose, predict, fix/modify as required BioMEMS analyzer

  5. Important Bio-med Areas • Monitors - Implanted; data via wireless. • Pharmacy-on-Chip provides medication • Gene modification • Nano-robotics for body maintenance and repair

  6. Simple Bio Implants wireless Wireless Personal monitoring

  7. Cosmetic Surgery • Popular • Standard library • Computerized • Mostly robotic (CAD-like)

  8. Early Bio Detector 500 µm long, 100 µm wide and about 1 µm thick IBM Pathogen/Bad Gene Detector

  9. Lab-on-Chip DNA can be amplified, separated and identified on a chip

  10. Lab on Chip Diagram

  11. Portable DNA Examples Caliper Tech. NanoChip® Electronic Microarray “pumping occurs by applying electric voltage to fluid. Sandia

  12. Sight Restoration 2015 Or link directly to iHUD

  13. FluidFocus Lens Phillips

  14. Sight Restoration 2055 • Retina regeneration • Optic nerve repair • Replacement optics • Grown and transplanted bio-parts • Moving toward eye grown in place

  15. Turbines Tweezers Cutters Detectors Sensors Pumps Legs Wireless Jets More Fantastic Journey?

  16. Death • Intervention up to age 80 • Euthanasia acceptable, but not suicide • You may be reactivated in suicide for obligations • Immortality research was banned in 2025 • Near-mortality is feasible; neg. consequences

  17. Birth in the Brave New World • Parents/Donors DNA QC’d • Gene “adjustment” OK • No super babies allowed • Minor modification; gene defect repair • Gene libraries; limited use • Will birth parents matter?

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