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Chapter 3 Macromolecules

Chapter 3 Macromolecules. Chemical Bonding and Water in Living Systems Strong and Weak Chemical Bonds. Covalent bonds ( Figure 3.1 ) are strong bonds that bind elements in macromolecules . Covalent Bonding.

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Chapter 3 Macromolecules

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  1. Chapter 3 Macromolecules

  2. Chemical Bonding and Water in Living SystemsStrong and Weak Chemical Bonds

  3. Covalent bonds (Figure 3.1) are strong bonds that bind elements in macromolecules.

  4. Covalent Bonding

  5. Weak bonds—such as hydrogen bonds (Figure 3.2), van der Waals forces, and hydrophobic interactions—also affect macromolecular structure, but through more subtle atomic interactions.

  6. Hydrogen Bonding

  7. A variety of functional groups containing carbon atoms are common in biomolecules (Table 3.1) and in the folding of complex biomolecules.

  8. An Overview of Macromolecules and Water as the Solvent of Life

  9. Understanding the relative composition of a bacterial cell (Table 3.2) helps us to understand the metabolic needs of the organism.

  10. The bacterial cell is about 70% water, with over one-half of the dry portion being made up of protein and one-quarter being made up of nucleic acids.

  11. Proteins (Figure 3.3a) are polymers of monomers called amino acids. Nucleic acids (Figure 3.3b) are polymers of nucleotides and are found in the cell in two forms, ribonucleic acid (RNA) and deoxyribonucleic acid (DNA).

  12. Lipids (Figure 3.3d) have both hydrophobic (nonpolar) and hydrophilic (polar) properties. They play crucial roles in membrane structure and as storage depots for excess carbon.

  13. The cohesive and polar properties of water promote chemical interaction and help shape macromolecules into functional units.

  14. PART II Noninformational MoleculesPolysaccharides

  15. Sugars combine into long polymers called polysaccharides.

  16. The relatively simple yet eloquent structure of the polysaccharides (Figure 3.4) and their derivatives (Figure 3.5) makes them the most abundant natural polymer on Earth and allows them to be used for metabolism, as a component of information transfer molecules (Figure 3.8), and for cellular structure.

  17. Nucleotides

  18. Glycosidic bonds (Figure 3.6) combine monomeric units (monosaccharides) into polymers (polysaccharides), all with a carbon-water (carbohydrate) chemical composition approaching (CH2O)n.

  19. The two different orientations of the glycosidic bonds that link sugar residues impart different properties to the resultant molecules. Polysaccharides can also contain other molecules such as proteins or lipids, forming complex polysaccharides.

  20. Lipids Lipids are amphipathic—they have both hydrophilic and hydrophobic components. This property makes them ideal structural components for cytoplasmic membranes.

  21. Simple lipids (triglycerides) are composed of a glycerol molecule with fatty acids (Figure 3.7) covalently linked in ester (Bacteria) or ether (Archaea) bonds.

  22. Many lipids draw their polar characteristics from complex, non–fatty acid groups connected to carbon 1 or 3 of glycerol (Figure 3.7).

  23. Informational MoleculesNucleic Acids

  24. The nucleic acids deoxyribonucleic acid (DNA) and ribonucleic acid (RNA) are macromolecules composed of monomers called nucleotides. Therefore, DNA and RNA are polynucleotides. Without a phosphate, a base bonded to its sugar is referred to as a nucleoside.

  25. All nucleotides have a phosphate group and a five-carbon sugar, with the sugar being ribose (–OH at carbon 2) in RNA or deoxyribose (–H at carbon 2) in DNA (Figure 3.10).

  26. It is the primary structure, or order, of pyrimidine and purine bases (Figure 3.9) connected by the phosphodiester bond (Figure 3.11) that gives nucleic acids their information-storing capacity.

  27. Both RNA and DNA are informational macromolecules. RNA can fold into various configurations to obtain secondary structure.

  28. Amino Acids and the Peptide Bond Although the -carbon of an amino acid can form four covalent bonds like other carbon atoms, the groups bonding to the -carbon are very specific.

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