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University of Cincinnati: Biomonitoring & Imaging Facilities Overview

The University of Cincinnati's Center for Environmental Genetics offers cutting-edge biomonitoring and imaging services, led by an expert team including Dr. Glenn Talaska and Dr. Marian Miller. Our core services include consultation and analysis on DNA adducts, carcinogen metabolites, enzyme assays, and histological phenotyping. We focus on identifying exposure interactions and their effects on health, offering comprehensive strategies for biomarker assessment in human and animal studies. Our aim is to enhance understanding of exposure effects while reducing misclassification in research.

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University of Cincinnati: Biomonitoring & Imaging Facilities Overview

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  1. University of CincinnatiCenter for Environmental GeneticsBiomonitoring and Imaging Facilities and Services Core

  2. Biomonitoring and Imaging Facilities and Services Core Core Members Glenn Talaska, Ph.D., CIH, Core Leader Marian Miller, Ph.D., Imaging Head Stacey Andringa, RA2, Imaging and Analysis Consultative Resources: Robert Bornschein, Ph.D. Scott Clark, Ph.D., CIH Carol Rice, Ph.D., CIH Howard Shertzer, Ph.D. David Warshawsky, Ph.D. CEG

  3. Biomonitoring and Imaging Facilities and Services Core Services Consultation, Analysis and Training Related to: DNA Adduct Analysis (Talaska, Warshawsky) Carcinogen Metabolites (Warshawsky, Talaska) Radical/Electrophile Scavenger and Enzyme Assays (Shertzer) Mass Spectroscopy Referral (Warshawsky) Imaging and Histological Phenotyping (Miller) CEG

  4. Biomonitoring and Imaging Facilities and Services Core Services (Cont.) Consultation Regarding: Review and Critique Exposure Assessment Strategies (Rice, Bornschein, Clark, Talaska) Selection of Exposure Metrics (Rice, Clark, Talaska) Exposure Reconstruction (Rice) Review Exposure Data (Rice, Talaska) Biological Monitoring (Talaska) CEG

  5. Biomarkers in human and animal studies can: • Reduce Misclassification • Document the extent of effect modification • Exposure : Exposure Interactions • Gene : Exposure Interactions • Determine Mechanisms • Serve as outcome variables

  6. Interactions: Effects of Age, Sex, etc Effects of Chronic Exposure (Cumulative Effects) Effects of Concomitant Exposure Additive Antagonistic Potentiative Synergistic

  7. Arsenic and PAH Interactions Finding the Mechanism(s) of Actions Craig Evans Andy Maier Alvaro Puga Brenda Schumann Glenn Talaska

  8. Arsenic and PAH Disease Interactions • Lung Cancer • Smoking and Occupational As exposure • As comutagenesis with DNA-reactive agents? • Skin Cancer • Synergy Unknown

  9. R= 0.54 M= 5220 B=-800 P=0.11

  10. Carcinogen-DNA Adducts are Increased in Exfoliated Urothelial Cells of Wives of Smokers: Biological Monitoring of Passive Smoke Exposure Scott Henn, Brenda Schumann and Glenn Talaska Department of Environmental Health

  11. Biomarkers in human and animal studies can: • Reduce Misclassification • Document the extent of effect modification • Exposure : Exposure Interactions • Gene : Exposure Interactions • Determine Mechanisms • Serve as outcome variables

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