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NODE 0 mRS 0: 13.6% (n=551) mRS 1: 19.4% (n=785) mRS 2: 14.7% (n=597) mRS 3: 16.5% (n=668)

DAY-90 mRS. NODE 0 mRS 0: 13.6% (n=551) mRS 1: 19.4% (n=785) mRS 2: 14.7% (n=597) mRS 3: 16.5% (n=668) mRS 4: 21.1% (n=855) mRS 5: 7.0% (n=324) mRS 6: 6.7% (n=271). Day-30 mRS > 3. Day-30 mRS ≤ 3. NODE 2 mRS 0: 0.1% (n=2) mRS 1: 1.8% (n=32) mRS 2: 4.2% (n=76)

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NODE 0 mRS 0: 13.6% (n=551) mRS 1: 19.4% (n=785) mRS 2: 14.7% (n=597) mRS 3: 16.5% (n=668)

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  1. DAY-90 mRS • NODE 0 • mRS 0: 13.6% (n=551) • mRS 1: 19.4% (n=785) • mRS 2: 14.7% (n=597) • mRS 3: 16.5% (n=668) • mRS 4: 21.1% (n=855) • mRS 5: 7.0% (n=324) • mRS 6: 6.7% (n=271) Day-30 mRS > 3 Day-30 mRS ≤ 3 • NODE 2 • mRS 0: 0.1% (n=2) • mRS 1: 1.8% (n=32) • mRS 2: 4.2% (n=76) • mRS 3: 19.4% (n=353) • mRS 4: 43.6% (n=794) • mRS 5: 17.4% (n=317) • mRS 6: 13.5% (n=246) • NODE 1 • mRS 0: 24.6% (n=549) • mRS 1: 33.8% (n=753) • mRS 2: 23.4% (n=521) • mRS 3: 14.1% (n=315) • mRS 4: 2.7% (n=61) • mRS 5: 0.3% (n=7) • mRS 6: 1.1% (n=25) Day-30 mRS ≤ 1 Day-30 mRS > 1 Day-30 mRS ≤ 4 Day-30 mRS > 4 • NODE 3 • mRS 0: 46.3% (n=500) • mRS 1: 44.9% (n=484) • mRS 2: 5.6% (n=60) • mRS 3: 1.3% (n=14) • mRS 4: 0.7% (n=7) • mRS 5: 0.1% (n=1) • mRS 6: 1.2% (n=13) • NODE 4 • mRS 0: 4.3% (n=49) • mRS 1: 23.4% (n=269) • mRS 2: 40.0% (n=461) • mRS 3: 26.1% (n=301) • mRS 4: 4.7% (n=54) • mRS 5: 0.5% (n=6) • mRS 6: 1.0% (n=12) • NODE 5 • mRS 0: 0.2% (n=2) • mRS 1: 2.5% (n=29) • mRS 2: 6.3% (n=73) • mRS 3: 28.8% (n=334) • mRS 4: 52.7% (n=612) • mRS 5: 4.0% (n=58) • mRS 6: 4.6% (n=53) • NODE 6 • mRS 0: 0.0% (n=0) • mRS 1: 0.5% (n=3) • mRS 2: 0.5% (n=3) • mRS 3: 2.9% (n=19) • mRS 4: 27.6% (n=182) • mRS 5: 39.3% (n=259) • mRS 6: 29.3% (n=193) Thrombolytic: No Day-30 mRS ≤ 0 Day-30 mR S> 0 Age ≤ 70.5 years Age >70.5 years Thrombolytic: Yes • NODE 7 • mRS 0: 78.3% (n=349) • mRS 1: 17.7% (n=79) • mRS 2: 2.7% (n=12) • mRS 3: 0.2% (n=1) • mRS 4: 0.2% (n=1) • mRS 5: 0.0% (n=0) • mRS 6: 0.9% (n=4) • NODE 8 • mRS 0: 23.9% (n=151) • mRS 1: 63.9% (n=405) • mRS 2: 7.6% (n=48) • mRS 3: 2.1% (n=13) • mRS 4: 0.9% (n=6) • mRS 5: 0.2% (n=1) • mRS 6: 1.4% (n=9) • NODE 9 • mRS 0: 0.0% (n=0) • mRS 1: 2.8% (n=15) • mRS 2: 8.3% (n=44) • mRS 3: 37.5% (n=200) • mRS 4: 46.7% (n=249) • mRS 5: 2.4% (n=13) • mRS 6: 2.3% (n=12) • NODE 10 • mRS 0: 0.3% (n=2) • mRS 1: 2.2% (n=14) • mRS 2: 4.6% (n=29) • mRS 3: 21.3% (n=134) • mRS 4: 57.8% (n=363) • mRS 5: 7.2% (n=45) • mRS 6: 6.5% (n=41) • NODE 11 • mRS 0: 0.0% (n=0) • mRS 1: 0.7% (n=3) • mRS 2: 0.5% (n=2) • mRS 3: 1.6% (n=7) • mRS 4: 22.6% (n=101) • mRS 5: 37.4% (n=167) • mRS 6: 37.4% (n=167) • NODE 12 • mRS 0: 0.0% (n=0) • mRS 1: 0.0% (n=0) • mRS 2: 0.5% (n=1) • mRS 3: 5.7% (n=12) • mRS 4: 38.2% (n=81) • mRS 5: 43.4% (n=92) • mRS 6: 12.3% (n=26) Figure e-1. Title:Ordinal tree model for predicting day-90 stroke outcome by modified Rankin Scale score (mRS) (n=4051). Legend: Each tree node contains day-90 mRS values: mRS of 0 = no symptoms; mRS of 1 = no significant disability; mRS of 2 = Slight disability; mRS of 3 = moderate disability; mRS of 4 = moderately severe disability; mRS of 5 = severe disability; mRS of 6 = death; B-NIHSSS=Baseline National Institutes of Health Scale score; B-SBP=Baseline systolic blood pressure; CHF=congestive heart failure B-NIHSSS ≤ 14.5 B-NIHSSS > 14.5 CHF: Yes CHF: No • NODE 13 • mRS 0: 0.0% (n=0) • mRS 1: 3.9% (n=11) • mRS 2: 11.5% (n=32) • mRS 3: 44.1% (n=123) • mRS 4: 36.2% (n=101) • mRS 5: 2.2% (n=6) • mRS 6: 2.2% (n=6) • NODE 14 • mRS 0: 0.0% (n=0) • mRS 1: 1.6% (n=4) • mRS 2: 4.7% (n=12) • mRS 3: 30.3% (n=77) • mRS 4: 58.3% (n=148) • mRS 5: 2.8% (n=7) • mRS 6: 2.4% (n=6) • NODE 15 • mRS 0: 0.0% (n=0) • mRS 1: 0.0% (n=0) • mRS 2: 0.75% (n=1) • mRS 3: 0.75% (n=1) • mRS 4: 17.3% (n=23) • mRS 5: 27.8% (n=37) • mRS 6: 53.4% (n=71) • NODE 16 • mRS 0: 0.0% (n=0) • mRS 1: 0.9% (n=3) • mRS 2: 0.3% (n=1) • mRS 3: 1.9% (n=6) • mRS 4: 24.8% (n=78) • mRS 5: 41.4% (n=130) • mRS 6: 30.6% (n=96)

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