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The Role of APE1 and Mutations in Genome Instability and Cancer Progression

This study delves into the interplay between APE1 and ANPG in driving genome instability, particularly in the context of APC and TP53 mutations. It highlights the AID-mediated demethylation of gene promoters and discusses how these processes influence the transcription of various genes, including those regulated by Myc. The implications for angiogenesis, erythropoiesis, and cellular proliferation are examined, along with the role of HIF-1a and OGG1. Understanding these connections is crucial for developing targeted cancer therapies.

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The Role of APE1 and Mutations in Genome Instability and Cancer Progression

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  1. + + + + + + + Figure 4 Genome instability Genome instability APE1/ ANPG Progression Progression APC mutated Pol b FEN1 APE1 AID-mediated demethylation of gene promoters Transcription of several genes TDG/MBD4 TP53 mutated Transcription of Myc-regulated genes Angiogenesis Erythropoesis Proliferation Progression HIF-1a OGG1

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