SlideServe
Télécharger Obtenir Pro
Menu
Accueil Pro
Préférences
ApparenceLight Aide et commentaires
© SlideServe · v2026

Curation of Models: The Rewarding Journey in Systems Biology

hila avatar
hila
17 diapositives · 348 Views · Oct 20, 2014

The process of curating models in systems biology can be both painstaking and rewarding. Key challenges include incomplete information, missing initial conditions, and software compliance issues. Common frustrations highlight the need for clear communication with authors. However, the rewards are significant, with valuable learning experiences gained through model integration, such as the Yeast Pheromone Pathway and Cell Cycle. This training not only enhances understanding but also prepares aspirants for the job market, where such skills are increasingly in demand.

#curation of models: the rewarding journey in systems biology #curation of models: the rewarding journey in systems biology ppt #powerpoint #presentation
Curation of Models: The Rewarding Journey in Systems Biology - slide 1
01 / 17Curation of Models: The Rewarding Journey in Systems Biology
1 / 17

Télécharger la présentation

Curation of Models: The Rewarding Journey in Systems Biology
Une image / un lien ci-dessous est fourni (tel quel) pour télécharger la présentation

Politique de téléchargement : le contenu du site vous est fourni TEL QUEL pour votre information et votre usage personnel ; il ne peut être vendu, concédé sous licence ni partagé sur d’autres sites sans l’accord de son auteur.Le contenu vous est fourni TEL QUEL, pour votre information et votre usage personnel uniquement. Téléchargez la présentation en cliquant sur ce lien. Lors du téléchargement, si vous ne parvenez pas à télécharger une présentation, l’éditeur a peut-être supprimé le fichier de son serveur.Pendant le téléchargement, si vous ne parvenez pas à obtenir une présentation, le fichier a peut-être été supprimé par l’éditeur.

F I N

Plus de contenu associé

Transcription de la présentation

  1. Curation of models: Painstaking effort or rewarding activity? Harish Dharuri Monday, October 20, 2014 Second Biomodels.net Training Camp

  2. What makes it painstaking… • Incomplete information in the paper • Missing • Initial Conditions • Parameter values • Lack of correspondence between simulation result and figures given in the paper. • Typo’s in model equations or just outright wrong representation. • Unresponsive authors.

  3. What makes it painstaking… • Software issues: SBML compliance. • Balance the need to make models compatible across the spectrum with aesthetics of model representation.

  4. What makes it rewarding…and there are many reasons • Learning • Learning • Learning

  5. Examples in Model Integration • Yeast Pheromone Pathway and Cell Cycle • BIOMD0000000032 and BIOMD0000000056 • Calcium Dynamics

  6. Yeast Pheromone Pathway CDC28+Far1PP: Leads to Cell Cycle Arrest

  7. Far1PP-CDC28 time profile

  8. Budding Yeast Cell Cycle, Chen et al (2004)

  9. Time Series – Cell Cycle Model

  10. Kegg Pathway

  11. CLN1,2,3 Mutant – G1 Arrest

  12. Recap • What we are doing… • Merging the Yeast Pheromone model and the Cell cycle model. • Far1PP-CDC28 (ComplexN) inhibits Cyclins (CLN1, CLN2 and CLN3) in the cell cycle model. • Inference made from literature. • What we hope to see… • Cell cycle stop in the G1 phase. • Needs to look like experimental data from CLN (1,2,3) mutants.

  13. Introduction of Pheromone mating factor Dynamics of the Merged Model - DNA synthesis

  14. Introduction of Pheromone mating factor Dynamics of the Merged Model – CKI profile

  15. Calcium signaling pathway

  16. Conclusions • What makes it painstaking • Issues with • Publications • Software • Authors don’t like me  • What makes it rewarding • Offers a terrific learning experience • Ideal training for a Systems Biology aspirant

  17. Conclusions • Another Issue • Employability with this skill set • What is the market demand/perception