1 / 4

The functional role of neural activity preceding  memory formation

The functional role of neural activity preceding  memory formation. BUCNI project presentation 19 Feb 2009. Leun Otten & Matthias Gruber. • Part of BBSRC project grant application • Aim: to understand the neural correlates of anticipatory processes in encoding • MEG and fMRI. Event.

hinto
Télécharger la présentation

The functional role of neural activity preceding  memory formation

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. The functional role of neural activity preceding  memory formation BUCNI project presentation19 Feb 2009 Leun Otten & Matthias Gruber • Part of BBSRC project grant application • Aim: to understand the neural correlates of anticipatory processes in encoding • MEG and fMRI

  2. Event Event Event Event Time Background • Neural activity elicited by an event can index its successful encoding into memory • Recently, shown that encoding is also influenced by activity before an event • Important for several reasons • Largely unknown what brain regions underlie encoding-related pre-stimulus activity • EEG work suggests role for semantic preparation

  3. ROSE Incidental study phase CAT Recognition memory test Delay (~20 min) TABLE In scanner Outside scanner • 120 words in living/non-living and alphabetic/non-alphabetic study tasks • 120 null events • Cue-word and inter-trial intervals optimized to allow maximum separation of activity before and after word onset o x Time o Current study • Aim: to assess which brain regions show activity that precedes memory formation in semantic and non-semantic study tasks • Design: • Study phase:

  4. Questions/contrasts of interest • Basic contrast is between study items that are later remembered vs. forgotten (‘subsequent memory effects’) • Which regions show pre-stimulus subsequent memory effects in the semantic study task? LIFG, MTL, PPC, midbrain? Do these regions overlap with those differentiating semantic vs. non-semantic preparation? • Which regions (if any) show pre-stimulus effects in the non-semantic study task? • Is there overlap between the regions demonstrating pre- and post-stimulus effects? • Does pre-stimulus activity predict an individual’s overall memory performance? fMRI methods Scanning • Rapid event-related fMRI sequence • Whole-head scanning • Two sessions of about 25 min each plus structural • 16 subjects with acceptable memory performance (twenty 1.5-hour slots) • SPM, modeling pre- and post-stimulus activity simultaneously, random effects analyses

More Related