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Monosaccharides

Monosaccharides. Cyclic Form of Monosaccharides 1. Glucose. Glucose is prepared by: 1. hydrolysis of sucrose 2. hydrolysis of starch Glucose is found in blood stream Found in tissue fluids If found in urine, it is an indicator of diabetes ( glucosuria )

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Monosaccharides

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  1. Monosaccharides

  2. Cyclic Form of Monosaccharides1. Glucose

  3. Glucose is prepared by: 1. hydrolysis of sucrose 2. hydrolysis of starch • Glucose is found in blood stream • Found in tissue fluids • If found in urine, it is an indicator of diabetes (glucosuria) • Glucose may show up in urine during extreme excitement (emotional glucosuria) or after ingestion of a large amount of sugar (alimentary glucosuria)

  4. 2. Galactose

  5. Glucose & Galactose are epimers. • Epimers: are 2 sugars that differ only in about a single carbon atom. D-galactoseepimerase D-glucose • Galactosuria Is a severe inherited disease results in the inability of infants to metabolize galactose because of a deficiency in either: 1. Galactose-1-phosphate-uridyl transferase (GALT) 2. Galactokinase (GALK) As a result the galactose concentration will increase in blood and urine (galactosuria)

  6. 3. Fructose

  7. Fructose is often called fruit sugar or levulose • Can be prepared by hydrolysis of sucrose • It also can be prepared by hydrolysis of Inulin • Fructose is 1.7 times sweeter than sucrose • Fructosemia: • An inherited disease (prevents the conversion of fructose to glucose) due to a deficiency of the enzyme fructose-1-phosphate aldolase. As a result fructose will increase in blood. symptoms may include vomiting, hypoglycemia, severe malnutrition

  8. Reactions of hexoses • Hexoses which are either aldoses or ketoses have reducing properties. • This reducing property of hexoses is the basis of the test for sugar in urine or blood. Gluconic acid

  9. Reduction of Monosaccharides Note: Accumulation of sorbitol in the eye is a major factor in the formation of cataracts due to diabetes.

  10. Fermentation • In the presence of yeast (or enzymes of yeast) glucose forms ethanol and carbon dioxide • Fructose can ferment but galactose can not. • Pentoses do not ferment in the presence of yeast.

  11. Formation of Phosphate Esters • Glucose forms phosphate esters at carbons 1, 6

  12. Amino Sugars • Amino sugars (hexosamines) contain an amino group on place of an –OH group. • Examples of natural amino sugars: • D- Glucosamine • D-galactosamine • D-mannosamine • Amino sugars are components of some antibiotics such asD- Glucosamine • and Carbomycin

  13. Amino Sugars • Amino sugars contain an -NH2 group in place of an -OH group • only three amino sugars are common in nature: D-glucosamine, D-mannosamine, and D-galactosamine

  14. Protein-Sugar Interactions • When the glucose level in the blood is elevated over a period of time, normal hemoglobin binds to glucose covalently. • The amount of glucosylated hemoglobin HbA1c in blood is used as a measure of the effectiveness of blood glucose control in a diabetic patient. • The concentration of HbA1c directly reflects the elevation of blood glucose over the preceding several days.

  15. In diabetic patient HbA1c is about 7 – 11% of the total hemoglobin (HbA) • In nondiabetic person this value ranges 4 – 6%.

  16. The word epimer means each of two isomers with different configurations of atoms around one of several asymmetric carbon atoms present. In chemistry, epimers are diastereomers that differ in configuration of only one stereogenic centre.

  17. The sugarsα-glucose and β-glucose are epimers. In α-glucose, the -OH group on the second (anomeric) carbon is in the direction opposite the methylene group on carbon C-6 (in the axial position). In β-glucose, the -OH group is oriented in the same direction as the methylene group (in the equatorial position). α-D-glucose β-D-glucose

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