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Exploring Inflammation and Its Impact on Health Across Lifespan

This document examines the role of inflammation in health, its significance in injury and tissue repair, and life expectancy trends in the United States across different demographics. It highlights how organs and tissues respond to injury, with key distinctions between epithelial and nerve cells. The discussion extends to obesity trends, their link to inflammation, autoimmune diseases, and cancer. It also addresses the safety factors in organ function and the implications of losing excess capacity with aging and injury.

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Exploring Inflammation and Its Impact on Health Across Lifespan

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  1. Inflammation and Course Themes Nancy Long Sieber, Ph.D. Sept. 12, 2011

  2. Life Expectancy of Americans at Various Ages in 1900-’02 and 2003By Age, Gender and Race Source : US CDC

  3. Challenges and Adaptation http://www.usc.edu/hsc/dental/PTHL312abc/312a/02/Graphics/figure01.gif

  4. http://www.siumed.edu/~dking2/crr/images/CR007b.jpg

  5. What is the significance of injury and toxicity? • Tissues differ in their capacity for repair • Epithelial cells are continuously replaced • Nerve cells, in general, do not divide • Organs also differ in their “safety factors” • All organs have some amount of excess capacity • With aging and injury, the excess capacity is lost, and this may lead to loss of function

  6. http://www.wirednewyork.com/hotels/marriott_marquis/images/marriott_marquis_elevators.jpghttp://www.wirednewyork.com/hotels/marriott_marquis/images/marriott_marquis_elevators.jpg

  7. Elevator cable for passenger elevators has a safety factor of about 11 http://www.gkivdo.com/gkii/wire_3.jpg

  8. Necrosis and Apoptosis http://pubs.niaaa.nih.gov/publications/arh25-3/image01.gif

  9. Developing human hand before web apoptosis http://www.i-am-pregnant.com/img/day48-hand.gif

  10. Developing hand after web apoptosis http://www.grg.org/breakingnews2001.htm

  11. Modified from: http://www.chrononhotonthologos.com/inactive/strokedr/hbothera.htm

  12. Inflammation http://www.uic.edu/classes/bios/bios100/lecturesf04am/inflammation01a.jpg

  13. Inflammation Pro-inflammatory cytokines IL-1 IL-6 TNF Positive acute phase reactants: LIVER Haptoglobin C3 Fibrinogen Serum amyloid A C-reactive Protein

  14. http://www.euromeds.co.uk/allergy-treatment-information.htm Allergen binds to IgE, which links to mast cells, triggering release of histamine.

  15. http://www.easterncarolinaent.com/Allergy-Triggers-copy.jpg Common Allergens

  16. Autoimmune Disease http://www.mctd.eu/images/AutoimmuneDisorder.jpg

  17. Cancer http://www.wellesley.edu/Chemistry/chem227/nucleicfunction/cancer/cancer.html

  18. http://www.wellesley.edu/Chemistry/chem227/nucleicfunction/cancer/cancer.htmlhttp://www.wellesley.edu/Chemistry/chem227/nucleicfunction/cancer/cancer.html

  19. Stress Responses

  20. Obesity Trends* Among U.S. AdultsBRFSS,1990, 2000, 2010 (*BMI 30, or about 30 lbs. overweight for 5’4” person) 2000 1990 2010 No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30%

  21. http://www.cancer.gov/cancertopics/factsheet/Risk/obesity

  22. http://www.lipidsonline.org/slides/slide01.cfm?q=abdominal+fat&pg=1http://www.lipidsonline.org/slides/slide01.cfm?q=abdominal+fat&pg=1

  23. http://mednews.wustl.edu/tips/page/normal/8947.html

  24. The women in this study did not gain weight, but they did have an increase in abdominal fat http://www.lipidsonline.org/slides/slide01.cfm?q=abdominal+fat&dpg=10

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