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RASEDATE S ELTESTIMISE STRATEEGIA JA TAKTIKA EESTIS LOOTE KROMOSOOMIHAIGUSED

Rasedate s

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RASEDATE S ELTESTIMISE STRATEEGIA JA TAKTIKA EESTIS LOOTE KROMOSOOMIHAIGUSED

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    1. RASEDATE SELTESTIMISE STRATEEGIA JA TAKTIKA EESTIS (LOOTE KROMOSOOMIHAIGUSED) MARI SITSKA SA TK HENDLABOR, MEDITSIINIGENEETIKA KESKUS Pealkiri nr 1Pealkiri nr 1

    2. Rasedate seltestimise strateegia Vereseerumi biokeemiliste markerite skriining raseduse II trimestril kaksiktest(double test) < 35 rasedatel alates 2003 sgisest < 37 s.o. seltest ka 35 ja 36 a rasedatel kolmiktest(triple test) teatud nidustusel Loote kromosoomianals vanuseriski nidustusel: >35 a kuni 2003 sgiseni >37 alates 2003 sgisest

    3. Rasedate vereseerumi biokeemiliste markerite skriining II trimestril 15-16 rasedusndal Mratakse vhemalt 2 markerit (kaksiktest) Vajadusel 3 (kolmiktest), 4 (quadruple test) Selale jvad positiivse testiga rasedad: riskigrupp Tenosus SD snniks 1:270 1:380 Seerumskriining: double/triple test kaksik-ja kolmiktest Seerumskriining: double/triple test nr 11 AFP ette punane tppSeerumskriining: double/triple test nr 11 AFP ette punane tpp

    4. Vereseerumi biokeemilised markerid AFP - ? - fetoproteiin (MSAFP) On loote spetsiifiline valk mida produtseeritakse peam. loote maksas. Loote uriin ? amnionivedelik ?ema veri SD puhul MSAFP ? hCG inimese konjugeerumata gonadotropiin SD puhul hCG?, seotud platsenta ebakpsusega vaba ? - hCG on tpsem uE3 - konjugeerumata striool uE3? SD Inhibin- A (SD puhul ?); PAPP-A (SD puhul ?)

    5. LOOTE KROMOSOOMIHAIGUSED: s.Down

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