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Scientific Abstracts

Scientific Abstracts. A few thoughts about abstracts in general. Your specific abstract format. Abstract purpose. Catch the interest of your reader. Help your reader decide whether they want/need to read the entire paper or not

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Scientific Abstracts

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  1. Scientific Abstracts A few thoughts about abstracts in general. Your specific abstract format.

  2. Abstract purpose Catch the interest of your reader. Help your reader decide whether they want/need to read the entire paper or not Provide a brief, but accurate account of your approach and results.

  3. Abstract Structure Blah, blah, significance and context, blah, blah, blah (one to two sentences). Your specific biological question/hypothesis, blah, blah (one sentence). Blah, blah, blah, your specific approach and results (maybe separate, maybe combined), blah. Blah blah, conclusions and how they relate to the context and significance, blah, blah, blah. Blah < 250-400. Note that the format for your research abstract specifies that it can be up to one page in 10 point font. DANGER!!!!!!!

  4. The hypothesis-driven project: example FMRP loss of function causes Fragile X syndrome (FXS) and autistic features.FMRP is a polyribosome-associated neuronal RNA-binding protein, suggesting that it plays a key role in regulating neuronal translation, but there has been little consensus regarding either its RNA targets or mechanism of action.Here, we use high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) to identify FMRP interactions with mouse brain polyribosomal mRNAs. FMRP interacts with the coding region of transcripts encoding pre- and postsynaptic proteins and transcripts implicated in autism spectrum disorders (ASD). We developed a brain polyribosome-programmed translation system, revealing that FMRP reversibly stalls ribosomes specifically on its target mRNAs.Our results suggest that loss of a translational brake on the synthesis of a subset of synaptic proteins contributes to FXS. In addition, they provide insight into the molecular basis of the cognitive and allied defects in FXS and ASD and suggest multiple targets for clinical intervention.

  5. The approach-driven project: example Despite decades of research, the structure and assembly of the nuclear pore complex (NPC), which is composed of ∼30 nucleoporins (Nups), remain elusive.Here, we report the genome of the thermophilic fungus Chaetomium thermophilum (ct) and identify the complete repertoire of Nups therein. The thermophilic proteins show improved properties for structural and biochemical studies compared to their mesophilic counterparts, and purified ctNups enabled the reconstitution of the inner pore ring module that spans the width of the NPC from the anchoring membrane to the central transport channel.This module is composed of two large Nups, Nup192 and Nup170, which are flexibly bridged by short linear motifs made up of linker Nups, Nic96 and Nup53.This assembly illustrates how Nup interactions can generate structural plasticity within the NPC scaffold. Our findings therefore demonstrate the utility of the genome of a thermophilic eukaryote for studying complex molecular machines.

  6. Your abstract format Your name and your mentor's name Title Background/Rationale: Background = Significance and context – carefully selected and very briefly stated. Rationale = Justification of your hypothesis – carefully selected evidence.

  7. Your abstract format Statement of the Purpose of the study: Aims and/or Hypotheses Actually, I would generally reverse the order and go with hypothesis and then aims. A good scientific hypothesis makes testable predictions. Your aim should have been to test those predictions.

  8. Your abstract format Methods Used = General strategy for achieving your specific aims. This is not the place for a detailed description of methods Explain what kind of experiment you did. If your methods departed significantly from standard methods in your field, briefly explain those differences and their significance.

  9. Your abstract format Results – Described in the context of your hypothesis and predictions.

  10. Your abstract format Conclusions/Discussion: Were your experiments conclusive? If so, was your hypothesis confirmed or rejected. How did these experiments advance your field? If they didn’t (it happens) what needs to be modified?

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