1 / 16

Arch Pathol Lab Med. 2007 Oct;131(10):1591-4.

Arch Pathol Lab Med. 2007 Oct;131(10):1591-4. A case of fatal disseminated Bartonella henselae infection (cat-scratch disease) with encephalitis. Fouch B, Coventry S.

huy
Télécharger la présentation

Arch Pathol Lab Med. 2007 Oct;131(10):1591-4.

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Arch Pathol Lab Med. 2007 Oct;131(10):1591-4. A case of fatal disseminated Bartonella henselae infection (cat-scratch disease) with encephalitis. Fouch B, Coventry S. Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY, USA.AbstractWe report a case of a previously healthy 6-year-old boy with cat-scratch disease, systemic dissemination, and encephalitis that led to his death. Autopsy revealed perivascular lymphocytic infiltrates and microglial nodules in the brain. To our knowledge, this finding has not been previously reported in B. henselae infection, possibly because of the paucity of material available for complete neuropathologic evaluation. This case illustrates the extreme severity of the spectrum with which cat-scratch disease can present and provides evidence of brain histopathology that may be representative of the disease

  2. J Emerg Med. 1995 Nov-Dec;13(6):769-72.An unusual presentation of cat scratch encephalitis. Chan L, Reilly KM, Snyder HS. Department of Emergency Medicine, Albany Medical College, New York, USA. AbstractCat scratch disease is an infectious illness that has been recognized since the 1880s; however, our understanding and knowledge of it is still evolving . It was not until 1991 that the etiologic species, Rochalimaea, was finally confirmed. Only recently have the breadth of its clinical spectrum and the population at risk been appreciated. We now realize that signs and symptoms that had been considered cardinal for diagnosis may be absent. Cat scratch disease was known to afflict primarily children and adolescent; however, the incidence of CSD is increasing in immunocompromised groups, The recent discovery of the infectious agent and improved understanding of the disease process have led to new approaches in diagnosis and treatment. We present a report of a patient with cat scratch disease who presented with seizure and altered mental status secondary to encephalitis

  3. Emerg Med J. 2008 Oct;25(10):703-4. Cat scratch disease presenting as acute encephalopathy. Cherinet Y, Tomlinson R. Department of Paediatrics, Bristol Royal Hospital for Children, Paul O'Gorman Building, Upper Maudlin Street, Bristol BS28BJ, UK. yonasc@hotmail.com Abstract An unusual case of primary meningo-encephalitis followed by partial complex seizure in a 9-year-old boy was found to be a symptom of cerebral Bartonella henselae infection or cat scratch disease. Despite one clinical relapse at 4 weeks post-presentation, he remained seizure free on carbamazepine for one year. Six months after stopping carbamazepine, however, he developed deja vu phenomena and absence seizures with EEG abnormality. Restarting carbamazepine improved his symptoms.

  4. Pediatr Int. 2008 Dec;50(6):823-4. Cat scratch disease with encephalopathy in a 9-year-old girl. Nishio N, Kubota T, Nakao Y, Hidaka H. Department of Pediatrics, Kakegawa City General Hospital, Kakegawa, Japan.

  5. Aust N Z J Med. 1997 Aug;27(4):454. Neuroretinitis and encephalopathy due to Bartonella henselae infection. McGrath N, Wallis W, Ellis-Pegler R, Morris AJ, Taylor W.

  6. Neurology. 1968 Oct;18(10):1031-3. Cat-scratch encephalitis. Pollen RH

  7. J Fla Med Assoc. 1957 Nov;44(5):491-2. Encephalitis in cat scratch disease; report of two cases. GAIR DR, WALLS WL.

  8. Minn Med. 1954 Nov;37(11):815-7. Cat-scratch disease associated with encephalitis and herpes zoster. FRICK PG.

  9. N Engl J Med. 1993 Jul 1;329(1):8-13. Cat scratch disease in Connecticut. Epidemiology, risk factors, and evaluation of a new diagnostic test. Zangwill KM, Hamilton DH, Perkins BA, Regnery RL, Plikaytis BD, Hadler JL, Cartter ML, Wenger JD. Meningitis and Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333. Comment in:N Engl J Med. 1993 Jul 1;329(1):53-4. N Engl J Med. 1994 Feb 3;330(5):370-1. Abstract BACKGROUND: Although cat scratch disease is commonly diagnosed in patients who have unexplained regional lymphadenopathy after encounters with cats, its epidemiology and the risk factors for disease are not clearly defined, and there is no generally accepted diagnostic test. METHODS: We conducted a physician survey to identify cases of cat scratch disease occurring over a 13-month period in cat owners in Connecticut. We interviewed both the patients (or their parents) and controls matched for age who owned cats. Serum from the patients was tested for antibodies to Rochalimaea henselae with a new, indirect fluorescent-antibody test. RESULTS: We identified 60 patients with cat scratch disease and 56 age-matched subjects. Patients were more likely than controls to have at least one pet kitten 12 months old or younger (odds ratio, 15), to have been scratched or bitten by a kitten (odds ratio, 27), and to have had at least one kitten with fleas (odds ratio, 29). A conditional logistic-regression analysis found that in kitten-owning households, patients were more likely than controls to have been scratched or bitten by a cat or kitten (odds ratio, 12.4; 95 percent confidence interval, 1.0 to 150). Of 45 patients, 38 had serum samples with titers of 1:64 or higher for antibody to R. henselae, as compared with 4 of 112 samples from controls (P < 0.001). The positive predictive value of the serologic test was 91 percent. Of 48 serum samples from patients' cats, 39 were positive for antibodies to R. henselae, as compared with positive samples from 11 of 29 control cats (P < 0.001). CONCLUSIONS: Cat scratch disease is strongly associated with owning a kitten, and fleas may be involved in its transmission. The serologic test for rochalimaea may be useful diagnostically, and our results suggest an etiologic role for this genus.

  10. METHODS: We conducted a physician survey to identify cases of cat scratch disease occurring over a 13-month period in cat owners in Connecticut. We interviewed both the patients (or their parents) and controls matched for age who owned cats. Serum from the patients was tested for antibodies to Rochalimaea henselae with a new, indirect fluorescent-antibody test. RESULTS: We identified 60 patients with cat scratch disease and 56 age-matched subjects. Patients were more likely than controls to have at least one pet kitten 12 months old or younger (odds ratio, 15), to have been scratched or bitten by a kitten (odds ratio, 27), and to have had at least one kitten with fleas (odds ratio, 29). A conditional logistic-regression analysis found that in kitten-owning households, patients were more likely than controls to have been scratched or bitten by a cat or kitten (odds ratio, 12.4; 95 percent confidence interval, 1.0 to 150). Of 45 patients, 38 had serum samples with titers of 1:64 or higher for antibody to R. henselae, as compared with 4 of 112 samples from controls (P < 0.001). The positive predictive value of the serologic test was 91 percent. Of 48 serum samples from patients' cats, 39 were positive for antibodies to R. henselae, as compared with positive samples from 11 of 29 control cats (P < 0.001). CONCLUSIONS: Cat scratch disease is strongly associated with owning a kitten, and fleas may be involved in its transmission. The serologic test for rochalimaea may be useful diagnostically, and our results suggest an etiologic role for this genus.

  11. CONCLUSIONS: Cat scratch disease is strongly associated with owning a kitten, and fleas may be involved in its transmission. The serologic test for rochalimaea may be useful diagnostically, and our results suggest an etiologic role for this genus.

  12. EDITORIAL N Engl J Med. 1993 Jul 1;329(1):53-4. Cat scratch disease. From feline affection to human infection. Margileth AM, Hayden GF. Comment on: N Engl J Med. 1993 Jul 1;329(1):8-13.

  13. J Neuroophthalmol. 2003 Mar;23(1):16-21. Magnetic resonance imaging abnormalities in cat-scratch disease encephalopathy. Seah AB, Azran MS, Rucker JC, Biousse V, Martin DF, Newman NJ. Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA, USA. ophtnjn@emory.edu Abstract A 23-year-old woman who presented with a branch retinal artery occlusion followed by encephalopathy showed, by brain magnetic resonance imaging, a nonenhancing lesion in the right parietal gray matter with normal diffusion-weighted imaging. Of 64 reported cases of cat-scratch encephalopathy with documented neuroimaging findings, only 12 (18.8%) have had abnormal imaging findings. The abnormalities have included cerebral white matter lesions, basal ganglia and thalamic lesions, and multifocal lesions in immunocompromised patients, but no gray matter lesions similar to those in this patient. The variety of neuroimaging findings supports multiple pathophysiologic mechanisms of central nervous system involvement in this disorder

  14. J Pediatr. 1999 May;134(5):635-8. Cat-scratch disease encephalopathy: a cause of status epilepticus in school-aged children. Armengol CE, Hendley JO. University of Virginia, Department of Pediatrics, Charlottesville, Virginia, USA. Abstract We describe 6 school-aged patients who presented with status epilepticus (SE) secondary to cat-scratch disease (CSD) encephalopathy to alert clinicians to this distinctive clinical entity. The hospital database for admissions during 1 year was reviewed for patients presenting with SE; 4 of 5 previously healthy school-aged children with SE had CSD encephalopathy based on elevated indirect fluorescent antibody titers to Bartonella henselae. CSD encephalopathy should be included in the differential diagnosis of school-aged children presenting with SE

  15. Neurology. 1997 Sep;49(3):876-8. Cat-scratch encephalopathy. Wheeler SW, Wolf SM, Steinberg EA. Department of Neurology, Kaiser Foundation Hospital, Los Angeles, CA, USA. Comment in: Neurology. 1998 Oct;51(4):1239. Abstract We present a case of cat-scratch disease in a 9-year-old girl, complicated by encephalopathy and seizures. Bartonella (formerly Rochalimaea) henselae is the causative agent in cat-scratch disease; methods now available for detection of this pleomorphic, gram-negative bacterium, including polymerase chain reaction amplification and indirect fluorescence antibody testing, may lead to changes in standard criteria used to verify a diagnosis of cat-scratch disease

  16. Pediatr Infect Dis J. 1995 Oct;14(10):866-9. Cluster of five children with acute encephalopathy associated with cat-scratch disease in south Florida. Noah DL, Bresee JS, Gorensek MJ, Rooney JA, Cresanta JL, Regnery RL, Wong J, del Toro J, Olson JG, Childs JE. Viral and Rickettsial Zoonoses Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. Abstract Between August 12 and September 27, 1994, five children in South Florida were hospitalized at a single hospital because of encephalopathy, presenting as status epilepticus, associated with cat-scratch disease (CSD). Diagnoses were confirmed by using an indirect fluorescent antibody test to detect antibody to Bartonella henselae, the causative agent of CSD. These cases represent the first cluster of CSD encephalopathy cases to be recognized in the United States. The patients lived within 7 miles of each other and all reported contact with pet or stray cats before developing regional lymphadenopathy and encephalopathy. A high proportion of 124 cats from the local area were seropositive (62%) or bacteremic (22%). This study suggests that B. henselae can be associated with geographically focal clusters of CSD encephalitis and should be considered in the evaluation of children with acute encephalopathy

More Related