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Introduction to Protein Science Architecture, Function, and Genomics Arthur M. Lesk

Introduction to Protein Science Architecture, Function, and Genomics Arthur M. Lesk. Chapter 2: Genomics and Proteomics P47-51 2008-11-10 Jeong , Da-Geum , UST. Chapter2: Genomics and Proteomics - Protein evolution. Flow of Change----------------------------- . Selected advantage.

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Introduction to Protein Science Architecture, Function, and Genomics Arthur M. Lesk

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  1. Introduction to Protein ScienceArchitecture, Function, and GenomicsArthur M. Lesk Chapter 2: Genomics and Proteomics P47-51 2008-11-10 Jeong, Da-Geum, UST

  2. Chapter2: Genomics and Proteomics - Protein evolution Flow of Change----------------------------- Selected advantage Disadvantage Exception: Silent mutation Ex: 3rd position in exons, untranslated regions Simplest change to a protein is the substitution of a single amino acid Then, what is the effect on the protein structure and function?

  3. Chapter2: Genomics and Proteomics - Protein evolution 1 Insertion 2 Deletion – cystic fibrosis 3 Transpositions – degraded in the ER Other type of change

  4. Chapter2: Genomics and Proteomics - Protein evolution • How do proteins develop new functions? • Divergence – progressive localized changes in sequence and structure • -> initially to change in specificity • -> ultimately to changes in the nature of the reaction catalysed • (2) Recruitment – one protein is adapted • (3)‘Mixing and matching’ of domains or modular evolution • large-scale structural changes • Individual domain-> gain of function, modified function, different processes. • Robustness of protein structure to mutations is • a maintenance of structure in spite of the divergence of sequences • during evolution

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