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Acetylcholine Receptor Binding Toxins

Bungarus multicinctus : κ -bungarotoxin toxin source. Link to BioQUEST Lesson. Hypothesis: Similar functioning proteins that bind the ACh receptors will have similar amino acid sequences. Naja naja : α -cobra toxin source. Results:

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Acetylcholine Receptor Binding Toxins

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  1. Bungarus multicinctus: κ-bungarotoxin toxin source Link to BioQUEST Lesson Hypothesis: Similar functioning proteins that bind the ACh receptors will have similar amino acid sequences. Naja naja: α-cobra toxin source Results: *Overlay: α-cobra toxin a (Y), κ-bungarotoxin (B), Cobratoxin (G), Erabutoxin (O) Acetylcholine Receptor Binding Toxins ACh Receptor *Phylogenetic Tree: Conclusion: Four (4) toxins that affect ACh receptors were found to be closely related evolutionarily resulting in proteins that have structural areas of similarity in their amino acid sequences. *Associated Amino Acid Residue Sequences: α-bungarotoxin κ-bungarotoxin Cobratoxin Erabutoxin

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