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Lecture 18 – siRNAs in Plants & Animals

Lecture 18 – siRNAs in Plants & Animals. BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F. Introductory. siRNA synthesis & function Plant paradigm Animal paradigm. Types of small silencing RNAs.

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Lecture 18 – siRNAs in Plants & Animals

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  1. Lecture 18 – siRNAs in Plants & Animals BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

  2. Introductory • siRNA synthesis & function • Plant paradigm • Animal paradigm

  3. Types of small silencing RNAs Small silencing RNAs: an expanding universe – Ghildiyal & Zamore – Nature Reviews Genetics - 2009

  4. Small RNA silencing pathways in Drosophila Small silencing RNAs: an expanding universe – Ghildiyal & Zamore – Nature Reviews Genetics - 2009

  5. Amplifying silencing Small silencing RNAs: an expanding universe – Ghildiyal & Zamore – Nature Reviews Genetics - 2009

  6. Plant endogenous small interfering RNA (endo-siRNA) biogenesis Small silencing RNAs: an expanding universe – Ghildiyal & Zamore – Nature Reviews Genetics - 2009

  7. Genomic sources of dsRNA triggers for endo-siRNAs in Drosophila and mammals Small silencing RNAs: an expanding universe – Ghildiyal & Zamore – Nature Reviews Genetics - 2009

  8. Feed-forward model for Piwi-interacting RNA Amplification Small silencing RNAs: an expanding universe – Ghildiyal & Zamore – Nature Reviews Genetics - 2009

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