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Lecture 18 – siRNAs in Plants & Animals

This lecture provides a comprehensive overview of small interfering RNAs (siRNAs) and their critical role in gene silencing in both plants and animals. We explore siRNA synthesis and function, comparing paradigms in plant biology with those in animal systems. Additionally, we discuss various types of small silencing RNAs, their biogenesis, and their involvement in silencing pathways, with a special focus on the insights provided by Ghildiyal and Zamore in the realm of small RNA research.

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Lecture 18 – siRNAs in Plants & Animals

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  1. Lecture 18 – siRNAs in Plants & Animals BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

  2. Introductory • siRNA synthesis & function • Plant paradigm • Animal paradigm

  3. Types of small silencing RNAs Small silencing RNAs: an expanding universe – Ghildiyal & Zamore – Nature Reviews Genetics - 2009

  4. Small RNA silencing pathways in Drosophila Small silencing RNAs: an expanding universe – Ghildiyal & Zamore – Nature Reviews Genetics - 2009

  5. Amplifying silencing Small silencing RNAs: an expanding universe – Ghildiyal & Zamore – Nature Reviews Genetics - 2009

  6. Plant endogenous small interfering RNA (endo-siRNA) biogenesis Small silencing RNAs: an expanding universe – Ghildiyal & Zamore – Nature Reviews Genetics - 2009

  7. Genomic sources of dsRNA triggers for endo-siRNAs in Drosophila and mammals Small silencing RNAs: an expanding universe – Ghildiyal & Zamore – Nature Reviews Genetics - 2009

  8. Feed-forward model for Piwi-interacting RNA Amplification Small silencing RNAs: an expanding universe – Ghildiyal & Zamore – Nature Reviews Genetics - 2009

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