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Erthropoiein (EPO)

Erthropoiein (EPO). By: Cody Kirkendoll. What is Erthropoiein ?. Erthropoiein is the hormone placed in charge of the signaling the monumental task of producing red blood cells. Also begins the synthesis of Hemoglobin, the element of the blood that carries oxygen . Where is it found?.

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Erthropoiein (EPO)

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  1. Erthropoiein(EPO) By: Cody Kirkendoll

  2. What is Erthropoiein? • Erthropoiein is the hormone placed in charge of the signaling the monumental task of producing red blood cells. • Also begins the synthesis of Hemoglobin, the element of the blood that carries oxygen.

  3. Where is it found? • EPO is created largely in the kidney, however 10% or so of it is created within the liver. • EPO travels through the blood stream to reach the bone marrow where it signals for the production of red blood cells.

  4. What Causes the Creation of EPO? • EPO is created when the kidney senses a lack of oxygen within the blood, often a sign of anemia or lack of red blood cells. • The kidney then creates EPO and releases it into the blood stream to enter bone marrow throughout the body.

  5. What is EPO’s Structure? • EPO is known as one of many Glycogens. • Glycogens are a protein that obtains an attached sugar, often used in signaling several aspects of blood creation and management.

  6. Where is EPO Most Active? • EPO is most active within the bone marrow where it signals the production of red blood cells.

  7. What Does a Lack of EPO Cause? • Normal amount of EPO ranges from 4 to 24 mU/ml (milliunits per milliliter) • A Lack of EPO causes Anemia or a severe lack of red blood cells. • Treatment includes intravaneous injection of Epoetin Alfa, an artificial substance that mimics EPO.

  8. What Does a Surplus of EPO Cause? • An excessive amount of EPO leads to a condition called Plycythemia Vera, or having too many red blood cells. • Too many red blood cells can thicken blood and lead to stroke, heart attack, damaged skin, etc… • Treatment includes draining blood for immediate relief of blood pressure and long-term treatment of Anagrelide to thin the blood.

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