1 / 8

Key Pathways Involving Organic Acid Metabolites

This slide outlines the primary metabolic pathways where organic acid metabolites play a crucial role. It covers the Citric Acid Cycle, Glycolysis, and the Urea Cycle, emphasizing the function of these metabolites in energy production and waste elimination.

iroatechnology
Télécharger la présentation

Key Pathways Involving Organic Acid Metabolites

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Organic Acid Metabolites: A Comprehensive Overview Organic acid metabolites play a crucial role in various metabolic pathways, contributing to energy production, cellular signaling, and detoxification. www.iroatech.com

  2. Overview of the Citric Acid Cycle Step 1: Acetyl-CoA Entry 1 The cycle begins with the entry of acetyl-CoA, derived from carbohydrate, fat, or protein metabolism. Step 2: Citrate Formation 2 Acetyl-CoA reacts with oxaloacetate, forming citrate, the first intermediate of the cycle. Step 3: Isomerization and Decarboxylation 3 Citrate undergoes a series of rearrangements and decarboxylation reactions, generating carbon dioxide and reducing equivalents. Step 4: Regeneration of Oxaloacetate 4 The cycle concludes with the regeneration of oxaloacetate, ready to accept another acetyl-CoA molecule, completing the cycle.

  3. Role of Organic Acids in Energy Production ATP Production Electron Carriers Metabolic Intermediates The citric acid cycle is a central hub for energy production, generating ATP, the primary energy currency of cells. The cycle produces reducing equivalents, NADH and FADH2, which carry electrons to the electron transport chain for further ATP synthesis. The intermediates of the cycle serve as precursors for biosynthesis of essential molecules, such as amino acids and heme.

  4. Common Organic Acid Metabolites Citric Acid Lactic Acid 1 2 A key intermediate in the citric acid cycle, found in citrus fruits and used as a food additive. Produced during anaerobic respiration in muscles and other tissues, contributing to muscle fatigue. Pyruvic Acid Acetic Acid 3 4 A central metabolite, connecting carbohydrate metabolism to the citric acid cycle. The main component of vinegar, produced by the fermentation of ethanol.

  5. Diagnostic Significance of Organic Acid Profiles Elevated Levels Potential Causes Methylmalonic Acid Vitamin B12 deficiency, inherited disorders Succinic Acid Mitochondrial disorders, Krebs cycle defects Lactic Acid Anaerobic metabolism, mitochondrial dysfunction Citric Acid Citrate synthase deficiency, metabolic overload

  6. Clinical Applications of Organic Acid Testing Metabolic Disorders Nutritional Deficiencies Organic acid metabolite testing can identify inborn errors of metabolism, such as organic acidemias and mitochondrial disorders. Testing can detect deficiencies in essential vitamins and minerals, such as vitamin B12, biotin, and thiamine. Gut Health Environmental Exposures Abnormal organic acid profiles may indicate dysbiosis, bacterial overgrowth, or impaired intestinal function. Elevated levels of certain organic acids can indicate exposure to toxins, heavy metals, or environmental pollutants.

  7. Conclusion and Future Directions Advancements in Technology Novel analytical techniques and high-throughput screening methods are improving the accuracy and efficiency of organic acid testing. Personalized Medicine Organic acid metabolites profiles can be used to tailor treatment strategies for individual patients based on their unique metabolic needs. Gut Microbiome Research Ongoing research is exploring the role of gut microbes in organic acid metabolism and their impact on human health.

  8. Contact Us 215 STOCKTON BLVD SEA GIRT, NJ 08750, US 734-265-0884 www.iroatech.com

More Related