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How to Get a K Award from NIH

How to Get a K Award from NIH

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How to Get a K Award from NIH

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  1. How to Get a K Award from NIH Nancy Halnon, M.D. Department of Pediatrics David Geffen School of Medicine at UCLA

  2. What is a K Award? • Career development award • Career enhancement award • Individual • Institutional • http://grants1.nih.gov/training/careerdevelopmentawards.htm

  3. Types of K Award • K 01 Mentored Research Scientist Development Award • K 02Independent Scientist Award • K 04 Modified Research Career Development Awards • K 05Senior Scientist Award • K 06Research Career Awards • K 07Academic Career Award • K 08Clinical Investigator Award (CIA) • K 10 Special Scientific Projects (NLM) • K 11Physician Scientist Award (Individual) (PSA) • K 12Mentored Clinical Scientist Development Program Award • K 14 Minority School Faculty Development Awards • K 15Dentist Scientist Award (Individual) • K 16Dentist Scientist Award (Program)

  4. Types of K Award • K 17Research Career Re-Entry Program • K 18 Career Enhancement Award for Stem Cell Research • K 20Scientist Development Award for Clinicians • K 21Scientist Development Award • K 22Career Transition Award • K 23Mentored Patient-Oriented Research Career Development Award • K 24Midcareer Investigator Award in Patient-Oriented Research • K 25 Mentored Quantitative Research Career Development Award • K 26 Midcareer Investigator Award in Mouse Pathobiology Research • K 30 Clinical Research Curriculum Award (CRCA) • K99/00 Pathway to Independence • K D1 Mental Health and/or Substance Abuse KD&A Grants (SAMHSA)

  5. K12 and K30 • Institutional awards • K12 • Award to institution to make individual awards based on K08 and K23 criteria • K30 • Award to institution to provide didactic training in translational or clinical research • Includes analytical training and ethics • Participants may be individuals with K awards or others including fellows • Completion of curriculum results in certificate

  6. K Award Wizard K99/K00

  7. K99/R00 • NIH Pathway to Independence (PI) Award – “You have no more than five years of postdoctoral training, you need one to two more years of postdoctoral mentored training, but expect to transition to an independent research position by the end of two years, and are seeking support for both the mentored training and your subsequent independent research project.”

  8. K99/K00 • Commit to 75% time for research and career development in year 1 +2 • Time may decrease to 50% in years 3-5 • Salary support $75,000 year 1+2 and project support increases to $249,000 after • Must be independent after 2 years and able to pass review • Requires submission of R01 application in independent phase

  9. K08 or K23 Awards • Specifically developed for clinician scientists in basic (K08), translational, or patient-oriented research (K23) • Salary support plus research project support • Length of support: 5 years (may be less depending on other awards) • Additional research training • Transferable • Guaranteed 75% research time • May apply for other funding (R03, R21, AHA, foundation, etc.) during award period • Loan repayment program

  10. Applications Are Judged By • Environment • Program • Candidate • Mentor(s) • Research plan

  11. K23 vs K08 • K08 • You are seeking salary and research support for a full-time supervised career development experience in area of health-related research that doesn't involve patients • K23 • You have completed specialty or sub-specialty training and are seeking salary and research support for a full-time supervised career development experience in patient-oriented research

  12. Patient-Oriented Research • “Research conducted with human subjects (or on material of human origin such as tissues, specimens, and cognitive phenomena) for which an investigator directly interacts with human subjects”

  13. Areas of Patient-Oriented Research • Mechanisms of human disease • Therapeutic interventions • Clinical trials • Development of new technologies

  14. Disease Related Research • Animal models • De-identified specimens • No patient interaction

  15. Eligibility (1) • Clinical doctoral degree or its equivalent: M.D., D.D.S., D.M.D., D.O., D.C., O.D., N.D., D.V.M., Pharm.D., Ph.D. • Must have completed their clinical training, including specialty and, if applicable, subspecialty training prior to receiving an award (K08 or K23) • Must identify a mentor with extensive research experience

  16. Eligibility (2) • Must be willing to spend a minimum of 75% full-time professional effort conducting research career development and clinical research • Applications may be submitted, on behalf of candidates, by domestic, non- Federal organizations • Must be citizens or noncitizen nationals of the United States, or have been lawfully admitted to the United States for permanent residence

  17. Not Eligible • Ineligible individuals include current and former principal investigators on NIH research project (R01), FIRST Awards (R29), comparable career development awards (K01, K07, or K08), sub-projects of program project (P01) or center grants (P50), and the equivalent • Former principal investigators of NIH Small Grants (R03) or Exploratory/Developmental Grants (R21) remain eligible

  18. Allowable Costs • Up to $75,000 per year salary support • Up to $25,000 per year project expenses can be used for: • tuition, fees, and books related to career development • research expenses, such as supplies, equipment and technical personnel • travel to research meetings or training • statistical services including personnel and computer time • Amount depends on budgetary considerations

  19. Scoring Applications • “The scientific review group will address and consider each of the following criteria in assigning the application's overall score, weighting them as appropriate for each application.” • Candidate • Appropriateness of and statements by Mentor, Co-Mentor(s), Consultant(s), and Collaborator(s) • Career Development Plan(including didactic training and advising committee) • Research Plan • Training in the Responsible Conduct of Research(can be part of didactic training) • Environment and Institutional Commitment to the Candidate (75% protected time, core and other facilities, didactic resources)

  20. THE CANDIDATE(PERSONAL STATEMENT) • Candidate’s Background • Career Goals and Objectives: Scientific Biography • Career Development/ Training Activities During Award Period • Training in the Responsible Conduct of Research

  21. Candidate Background • A description of the candidate's commitment to a career in patient-oriented research • Evidence of the candidate's potential to develop into an independent investigator • A description of immediate and long-term career objectives, explaining how the award will contribute to their attainment • A commitment of at least 75 percent effort to the clinical research program • Three sealed letters of recommendation addressing the candidate's potential for a research career

  22. Letters of Reference • 3 letters required • In addition to collaborators • In addition to mentor (sponsor) letter • Members of the advising committee may be acceptable • Provided in sealed unopened envelopes addressed to ‘PHS USE ONLY’

  23. Mentor • Established investigator in the field • Professor or associate professor • Nationally recognized • Currently holding a R01 (CRISP database) • Track record of previous trainees • Knowledgeable • Available and accessible • Interested in your career development

  24. How to Find Mentor(s) • Talk to senior faculty in your division or department • Medline search • CRISP database • Primary mentor, co-mentors • Within division, department, institution, or your geographic area?

  25. CRISP Database

  26. Career Development Plan • “Applications must contain a career development plan as well as a research plan.  The career development plan must justify the need for the requested period of support, be tailored to the prior research experience and career development needs of the candidate, and be designed to move the candidate from the mentored phase to the independent phase of their research career.”

  27. Didactic Training • “The didactic and the research aspects of the plan must be designed to develop the necessary knowledge and research skills in scientific areas relevant to the candidate's career goals. The candidate must demonstrate they have received training or will participate in courses such as: data management, epidemiology, study design, hypothesis development, drug development, etc., as well as the legal and ethical issues associated with research on human subjects. “

  28. Career Development • K30 program • GCRC courses • MS or MPH • Meetings, seminars, workshops, coursework • Training specific to your field • Training in the Responsible Conduct of Research • Frequent meetings with mentors and advising committee

  29. Career Development • Include course names, numbers, and content from course catalogue if available example- Research Ethics M261 • Advising committee can include mentors providing professional development as well as assistance in research field • Describe advising committee members qualifications and contribution to your career development

  30. Institutional Commitment • Department Chair • Standard content with statement describing commitment to protected time and promise of infrastructure • In addition to sponsor letter, collaborator letters, and reference letters

  31. Research Plan • Degree of relevance of the research plan to developing an independent research program focused on patient-oriented research. • Usefulness of the research plan as a vehicle for enhancing existing research skills as described in the career development plan. • Scientific and technical merit of the research question, design and methodology judged in the context of the candidate's previous training and experience.

  32. Research Plan • The research plan must have intrinsic research importance as well as serve as a suitable vehicle for learning the methodology, theories, and conceptualizations necessary for a well trained independent researcher. 

  33. RESEARCH PLAN

  34. Which Institute or Center? • Each K program is subject to the general guidelines of the Program Announcement. However, certain institutions award more funds or request slightly higher effort than what is in the general PA. Once a K program is identified and a likely institute is chosen, a visit to the institute's website should indicate whether there are variances from the standard. • Instructions, suggestions, sample exemplary applications at many Institutes websites

  35. Oh NO! My score is high • Critique Critique Critique!!!!

  36. Alternatives to K Award • Advanced research fellowship • Institutional support • American Heart Association, American Cancer Society, March of Dimes, etc. • R03, R21 awards • Private foundations or donors (Department or Medical school) • Sarnoff Scholar

  37. PLAN AHEAD!!!!! • 3 reference letters, institutional commitment letter, and sponsor statement • Formulate career development plan and gather assistance from advising committee and sponsor • Formulate and revise research plan • 3 months minimum after identifying a mentor and rough draft of a research plan • Contact program officer at Institute where your application will be reviewed

  38. Helpful Instructions • Several institutes have instructive samples, templates, or lessons http://www.niaid.nih.gov/ncn/grants/default.htm • Model K08 http://www.nhlbi.nih.gov/funding/training/redbook/k08model.htm • 2 sample K23 http://www.nhlbi.nih.gov/funding/training/redbook/k23models.htm