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Biosynthesis of peptide hormones

Biosynthesis of peptide hormones. DNA (gene). Hormone. Protein secretory pathway. Protein secretory pathway. rough endoplasmic reticulum. Secretory pathway. rough ER. Signal sequences & SRP. SRP (signal recognition particle). Signal sequences & SRP.

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Biosynthesis of peptide hormones

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  1. Biosynthesis of peptide hormones DNA (gene) Hormone

  2. Protein secretory pathway

  3. Protein secretory pathway rough endoplasmic reticulum

  4. Secretory pathway rough ER

  5. Signal sequences & SRP

  6. SRP (signal recognition particle) Signal sequences & SRP

  7. pro-opiomelanocortin polypeptide (POMC) b -lipotropin ACTH CLIP b -endorphin g -lipotropin a -MSH g -MSH MET-enk b -MSH Multiple hormone cleavage products

  8. testosterone estradiol Steroid hormone synthesis • tissues involved in steroid hormone synthesis:

  9. cholesterol Steroid hormone synthesis • synthesis occurs in

  10. Biosynthesis of steroids cholesterol (C27)

  11. Gluco- and mineralo-corticoid synthesis glucocorticoid mineralorticoid

  12. Androgen & estrogen synthesis androgen estrogens

  13. Vitamin D synthesis UV light liver, kidney

  14. Thyroid hormone synthesis • thyroid hormone synthesis • forms of active thyroid hormone:

  15. Thyroid hormone biosynthesis

  16. Biosynthesis of eicosanoids arachidonic acid

  17. Biosynthesis of eicosanoids

  18. Anti-inflammatory drugs & eisosanoids fatty acids phospholipase A arachidonic acid thromboxane leukotriene inflammation response

  19. Hormone delivery • endocrine: • paracrine: • autocrine: • neuroendocrine:

  20. Plasma transport of hormones

  21. Hormone turnover • typical half-life • peptide hormones • steroid & thyroid hormones

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