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A SYSTEM AND DEVICE FOR FOCAL tDCS: HIGH–DEFINITION(HD) tDCS

A SYSTEM AND DEVICE FOR FOCAL tDCS: HIGH–DEFINITION(HD) tDCS. Abhishek Datta Jeff Borckardt, Mark George, Mar Cortes, Dylan Edwards, Felipe Fregni, Eric Wassermann, Marom Bikson. Neural Engineering Laboratory - Department of Biomedical Engineering The City College of New York of CUNY.

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A SYSTEM AND DEVICE FOR FOCAL tDCS: HIGH–DEFINITION(HD) tDCS

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  1. A SYSTEM AND DEVICE FOR FOCAL tDCS: HIGH–DEFINITION(HD) tDCS Abhishek Datta Jeff Borckardt, Mark George, Mar Cortes, Dylan Edwards, Felipe Fregni, Eric Wassermann, Marom Bikson Neural Engineering Laboratory - Department of Biomedical Engineering The City College of New York of CUNY Neuromodulation Laboratory, Spaulding Rehabilatation Hospital Harvard Medical School

  2. TRANSCRANIAL DIRECT CURRENT STIMULATION (tDCS) -application of currents delivered through the scalp to modulate brain activity. -safe,easy to apply, CHEAP! -number of disorders, rehabilatation and cognitive enhancement

  3. Stimulation Electrodes SPATIAL TARGETING “Conventional” Sponge-based Transcranial DC Stimulation Brain Current flow and brain modulation

  4. Stimulation Electrodes SPATIAL TARGETING “High-Definition (HD)” Transcranial DC Stimulation Brain Current flow and brain modulation “Ring” Configuration

  5. FEM ANALYSIS OF TRANSCRANIAL ELECTROTHERAPY FOCALITY Conventional Transcanial (large pad) High-definition (HD) Transcanial (4x1 Ring)

  6. “CONVENTIONAL” tDCS

  7. 1 mA Datta et al., 2009 “CONVENTIONAL” tDCS Electric field Max Min

  8. HIGH DEFINITION (HD)- tDCS

  9. 2 mA Datta et al., 2009 HIGH DEFINITION (HD)- tDCS Electric field Max Min

  10. HD tDCS – 4x1 NIH-NINDSEric Wassermann, Egas Caparelli DáquerMUSCMark GeorgeJeff BorckardtBurke RehabilitationDylan EdwardsMar Cortes Harvard (Spaulding)Felipe Fregni ……. Hardware Development Clinical Trials Soterix Medical

  11. PILOT CLINICAL STUDY 1: EXPERIMENTAL PAIN (MUSC) “Setup”

  12. PILOT CLINICAL STUDY 1: EXPERIMENTAL PAIN (MUSC) Borckardt et al., under review Analgesic effects in an experimental pain model…… Significant effect for sensory thresholds.

  13. PILOT CLINICAL STUDY 2: COMBINED TES & MODELING (BURKE REHABILATATION) Targeting Validation Transcranial Electrical Stimulation (TES) – short high-intensity pulse that triggers motor response (MEP) Edwards et al., under review

  14. ANODE:F3CATHODE:AF7,AFz,FC5,FC1 Peak 66% Electric field/Current density 33% ANODE:C3 CATHODE:FC5,FC1,CP5,CP1 0 ANODE:P3CATHODE:CP5,CP1,PO7,POz PILOT CLINICAL STUDY 2: COMBINED TES & MODELING (BURKE REHABILATATION) Edwards et al., under review

  15. -Customizable (individualized therapy) Procedures, implants… Skull Defects / TBI Stroke Other configurations can be used: (4 X 4, 5X2…) based on application ADVANTAGE OF HD CONFIGURATIONS: -Retains advantages of conventional therapy -Cortical regions can be “selectively targeted” using a HD system.

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