GE Healthcare

1. GE Healthcare

2. GE Healthcare • ~$15B global business unit of GE • GE Healthcare Technologies • GE Healthcare Bio-Sciences • $1B in R&D • 42,500 employees worldwide • Headquartered in Chalfont St. Giles, United Kingdom • Sir William Castell, President & CEO ~ ~ GE Healthcare Revenues ($B) *Based on 2004 Financial Proforma

3. Research & Development Customer Needs Annual R&D Investment 1.2B • Drive Better Outcomes • Increased Productivity • Information Management • Enhanced Patient Satisfaction ($M) ~550 ‘02 ‘01 ‘03 ‘05 ‘06 ‘04

4. GE Healthcare Platforms DiagnosticPharma • Diagnostic Productivity • Targeted Imaging Agents Focus Sales ’03: $1.6B CAGR: ~12% Diagnostic Imaging Information Technology • Technology Innovation • Clinical Productivity • Globalization • Partnership • Whole Hospital • Performance ROI • Physician Workflow • Paperless, Filmless, Wireless • More Effective Drug Dev’t • In-vivo Diagnostics • Enabling Molecular Med. Focus Focus Focus Focus Sales ’03: $5.5B CAGR: ~10% Sales ’03: $2.7B CAGR: ~6% Sales ’03: $1.9B CAGR: ~30% Sales ’03: $1.1B CAGR: ~8% Molecular Imaging Hospital Productivity Clinical IT Systems Molecular Medicine Proteins Evolution Evolution Evolution Evolution Anatomical Imaging Drug Development Maintenance PACS CAGR = 2000 to 2003;

5. Evolving medical practice – 20th Centuryempirical medicine Visit your doctor with illness Symptom-based diagnosis (In-Vitro Diagnostics, Imaging) “Here… Try This” Treatment Recover or revisit

6. Time for a fundamental change… Cancer Heart Disease Brain Disorders One Person in Three Will Have Cancer 50% Die After 1st Heart Attack 20% Aged 75-84 Suffer From Alzheimer’s Disease

7. Genomics Development Preventive Medicine • Detect life threatening disease before symptoms appear • See drugs hitting their targets almost instantaneously • Determine patient candidacy for drugs • Bring to market life saving drugs tailored to individual’s genetic make-up faster • Human Genome Discovery • ‘88-’00: Mapped • ‘98-’10: Analyzing SNP’s Human Proteome Discovery ‘00-’20: Discovering Protein Relationships to Genes Disease Biomarkers identified from studies of the Human Genome & Proteome Targeted Chemistry Targeted chemistry that binds to and highlight biomarkers Imaging Technologies High-sensitivity, high-resolution scanners Genomics to Molecular Medicine to Preventive Medicine

8. Targeted Chemistry • Molecular Targets for Diagnostics and Therapeutics • Overactive cell receptors • Over/under-expressed proteins • Over/under-expressed genes • Gene mutations, omissions, multiple copies Molecular Target • Payload Chem • Label • Tracer • Therapeutic • Targeting Ligand • Antibody • Low-weight organic molecule • pharma chemistry • Viruses (gene therapy) Chemistry Delivers Targeting and Contrast or Therapy

9. Medical Imaging Evolution ’80sMainstream X-Ray-based Anatomical Imaging: XR, CT Ultrasound ’90sMainstream CT, MR, US Anatomical Imaging Digital Xray ‘00sMainstream Anatomical Registration of Functional Imaging: PET/CT, MR Next Mainstream Molecular Imaging+Molecular Therapeutics+Molecular Diagnostics • Emerging • MR Anatomical Imaging (Soft-Tissue Visualization) Emerging Functional ImagingMR, PET MR Spectroscopy (Characterization) Emerging Anatomical Registration of Molecular Imaging Molecular Therapeutics, Diagnostics & DI Emerging Image-guided Gene Therapy

10. Deeper Smaller Anatomic Detection Cellular Imaging (Receptors) Molecular Imaging (Protein Activity) Imaging Becoming Deeper & Broader • Broader • Portable Ultrasound • Focus Ultrasound & MR • Non Invasive Angiography • Non Invasive Colonography Change Drivers • Computational Speed & Power • Miniaturization & Software • Biochemistry & Signal Processing *Based on 2004 Financial Proforma

11. Informatics Source: Uzgiris, GE CRD Tjuvajev, Blasberg, Larson, MSKCC Molecular Imaging … Diagnostic Pharmaceuticals Biochemistry PET, MRI, MRSI DNA/Protein MicroArrays Biotechs Diagnostic Imaging Imaging Physics, Engineering MOLECULAR IMAGING Molecular Biology Affymetrix Pharmacology Pharmaceuticals Pull together an Interdisciplinary Approach

12. The Future … Personalized Medicine Pinpoint Detect Predict Prevent/Treat Imaging Protein In Vitro (IVD) Gene Assay Track and Verify Imaging, IVD MolecularDiagnostics MolecularImaging MolecularTherapeutics MolecularDiagnostics MolecularImaging MolecularTherapeutics Evolving medical practice – 21st Century Personalized Healthcare

13. Predict Diagnose Inform Treat New age of medicine… 21st Century Personalized Healthcare

14. Personalized Medicine Building Blocks Future Ubiquitous Ultrasound … As a Stethoscope Genomic Pathology in Clinic … P450 for Liver Metabolism Non-invasive Colonography … CT Enabled by an EMR Non-invasive Angiography … Volumetric CT Clinical Enterprise IT Offering … HCIT Proteomics in Clinical Diagnostics … Protein Arrays Today “Late Disease” “Specialized Diagnostics” “Early Health” • Physician-Centric • Symptom Based • Aggregate Therapies • Population Screening • Niche In Vitro Molecular Dx • High Sensitivity In Vivo Imaging • Patient-Centric • Broad-based, Molecular Dx • Payer Collaboration Digital Patient Records Paper Records Personalized EMR

15. The Future: Personalized Healthcare Clinical Certainty & Efficiency Diagnostics Growth … More Specific Diagnostics Personalization Integration Acquisition Diagnostic Complexity … Sophisticated Decision Support