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Analysis of Sema3a Expression Defects in Chd7 and hCHD7 Gene Knockdown Models

This study investigates the expression patterns of Sema3a in relation to defects induced by Chd7 and hCHD7 knockdowns. We observed various severities of defects, marked as severe and mild, in control (MO) and experimental (Chd7 MO, hCHD7 RNA) groups. The data suggests a concentration-dependent response, with varying percentages for severe defects (62%-100%) and mild defects (20%-80%). The findings contribute to our understanding of Chd7 function in neuronal development and its potential implications for related disorders.

jenette-miller
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Analysis of Sema3a Expression Defects in Chd7 and hCHD7 Gene Knockdown Models

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  1. Chd7 Mo Chd7 Mo + hCHD7 Co Mo + hCHD7 Control Figure S4 C E G A H B D F I Sema3aexpression pattern defects 62 78 100% 80% 60% 40% 20% 0% severedefects mild defects normal 43 40 28 17 11 3 2 1 + + + + + 10 ng Control MO 10 ng Chd7 MO 1,5 ng hCHD7 RNA

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