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In Vivo Trial Results of Ultrasonic Cough Stimulator: Promising Findings for Respiratory Health

This study by Jennifer C. Nitz, John Perrier, and Peter Cook aimed to determine the safety and efficacy of ultrasonic cough stimulation, essential for individuals with compromised cough ability. The results showed favorable cough response rates with the CoughStim device, indicating its potential in helping patients manage respiratory conditions. The study explored various frequencies and power levels, highlighting the device's ability to induce cough without discomfort. These findings underscore the importance of innovative solutions for respiratory health.

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In Vivo Trial Results of Ultrasonic Cough Stimulator: Promising Findings for Respiratory Health

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  1. In-vivo trial results of a novel ultrasonic cough stimulator Jennifer C. Nitz, PhD, MPhty, BPhty; John Perrier, BPhty; Peter Cook, MBBS, FANZCA, FCICM

  2. Aim • Establish: • Whether ultrasound (US) stimulation can safely stimulate cough. • Most efficient US frequency. • Whether single- or dual-sided stimulation is more effective. • Relevance • Ability to cough voluntarily is absent or diminished in many clinical situations, which may predispose patients to or prolong respiratory diseases.

  3. Method • Applied stimulation with CoughStim device to 15 nondisabled and 7 unable-to-cough volunteers: • Unilaterally: 8 frequencies and 2 power levels. • Bilaterally: 2 frequencies and 3 power levels.

  4. Results • Nondisabled subjects • Cough stimulated: • 80% at 0.58 MHz and 9 W unilaterally. • 75% at 0.58 MHz and 6 W bilaterally • Unable-to-cough subjects • Cough stimulated: • 71% at 0.54 MHz and 6 W bilaterally.

  5. Conclusion • CoughStim device: • Regularly and safely produced moderately strong cough response in subjects with or without ability to cough. • Produced this effect without causing undue discomfort.

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