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In-vivo trial results of a novel ultrasonic cough stimulator

In-vivo trial results of a novel ultrasonic cough stimulator. Jennifer C. Nitz, PhD, MPhty, BPhty; John Perrier, BPhty; Peter Cook, MBBS, FANZCA, FCICM. Aim Establish: Whether ultrasound (US) stimulation can safely stimulate cough. Most efficient US frequency.

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In-vivo trial results of a novel ultrasonic cough stimulator

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  1. In-vivo trial results of a novel ultrasonic cough stimulator Jennifer C. Nitz, PhD, MPhty, BPhty; John Perrier, BPhty; Peter Cook, MBBS, FANZCA, FCICM

  2. Aim • Establish: • Whether ultrasound (US) stimulation can safely stimulate cough. • Most efficient US frequency. • Whether single- or dual-sided stimulation is more effective. • Relevance • Ability to cough voluntarily is absent or diminished in many clinical situations, which may predispose patients to or prolong respiratory diseases.

  3. Method • Applied stimulation with CoughStim device to 15 nondisabled and 7 unable-to-cough volunteers: • Unilaterally: 8 frequencies and 2 power levels. • Bilaterally: 2 frequencies and 3 power levels.

  4. Results • Nondisabled subjects • Cough stimulated: • 80% at 0.58 MHz and 9 W unilaterally. • 75% at 0.58 MHz and 6 W bilaterally • Unable-to-cough subjects • Cough stimulated: • 71% at 0.54 MHz and 6 W bilaterally.

  5. Conclusion • CoughStim device: • Regularly and safely produced moderately strong cough response in subjects with or without ability to cough. • Produced this effect without causing undue discomfort.

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