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This document discusses the estimation of creatinine clearance (CCr) using the formula CCr = (U x V) / P, where U is urine creatinine concentration, V is urine flow rate, and P is plasma creatinine concentration. It references Jelliffe R's method for estimating CCr in patients with unstable renal function without a urine specimen (Am. J. Nephrology, 2002). Additionally, comparisons between estimated and measured CCr by various studies (Maire et al.) highlight different methods, including the MDRD and Cockcroft-Gault equations, addressing the accuracy and reliability of renal function assessments.
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Estimating CCr • C = (U x V)/P • Or, P x C = U x V
Reference • Jelliffe R: Estimation of Creatinine Clearance in Patients with Unstable Renal Function, without a Urine Specimen. Am. J. Nephrology, 22: 320-324, 2002.