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Estimating Creatinine Clearance: Methods and Comparisons in Renal Function Assessment

This document discusses the estimation of creatinine clearance (CCr) using the formula CCr = (U x V) / P, where U is urine creatinine concentration, V is urine flow rate, and P is plasma creatinine concentration. It references Jelliffe R's method for estimating CCr in patients with unstable renal function without a urine specimen (Am. J. Nephrology, 2002). Additionally, comparisons between estimated and measured CCr by various studies (Maire et al.) highlight different methods, including the MDRD and Cockcroft-Gault equations, addressing the accuracy and reliability of renal function assessments.

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Estimating Creatinine Clearance: Methods and Comparisons in Renal Function Assessment

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  1. Estimating CCr • C = (U x V)/P • Or, P x C = U x V

  2. Reference • Jelliffe R: Estimation of Creatinine Clearance in Patients with Unstable Renal Function, without a Urine Specimen. Am. J. Nephrology, 22: 320-324, 2002.

  3. Estimated vs Measured CCr

  4. Maire et al: CCr vs J + J

  5. Maire et al: CCr vs MDRD with prot/2

  6. Maire et al: CCr vs MDRD with urea

  7. Maire et al: CCr vs MDRD without urea

  8. Maire et al:CCr vs Cockroft-Gault

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