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Long-term Outcomes of the Very Elderly Admitted to ICUs in Canada: A Quality Finish?

This study examines the long-term outcomes of very elderly individuals admitted to ICUs in Canada, with a focus on the quality of end-of-life care and the impact on patients and their families. The study aims to improve clinical decision-making and communication to ensure better outcomes for this population.

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Long-term Outcomes of the Very Elderly Admitted to ICUs in Canada: A Quality Finish?

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  1. Long-term Outcomes of the Very Elderly Admitted to ICUs in Canada: A Quality Finish? Daren K. Heyland MD, MSc Queen’s University and Kingston General Hospital Kingston Ontario

  2. Background Globally, population is ageing In US, the number of persons aged 85 years or older is likely to grow from about 4 million in 2000 to 19 million by 2050 In Canada Currently 55-64 fast growing age group >80 second fast growing age group (25% increase from 2001-2005) Rate of growth projected to continue till 2031 when seniors would account for 25% of population (currently 13%) As the population ages, the proportion of patients with advanced medical diseases will rise and our health care system needs to adapt to this changing demographic

  3. Current ICU Utilization of Very Elderly in Ontario 18% 22%

  4. Biomedicalization of Aging Society views ageing negatively, as a disease for which medical intervention is normalized, necessary, and appropriate. The more high tech medicine one consumes; the more one forestalls aging. In this paradigm, use of life sustaining technology becomes the norm From Family’s perspective, caring is associated with everything being done Consequence is that we have a crisis where demand for critical resources outstrips supply and problem will only get worse

  5. Background Quality EOL Care Scare ICU Resources Aging of Society (Very) Elderly in the ICU?

  6. A Quality Finish? CMAJ 2006;174:627

  7. What Matters the Most to Quality of End of Life Care in Canada N= 440 Results from Patient’s Perspective Good Communication and Decision-Making? Heyland CMAJ 2006;174:627

  8. Improving EOL communication and decision making Greatest Improvements in EOL Care Improving EOL communication and decision making

  9. Failure to Engage Hospitalized Elderly Patients and Their Families • Multicenter survey of 283 80+ on hospital wards • Majority had thought of EOL wishes and could express preference for treatment at EOL • Less than 1/3 had spoken to health care professional • Fewer than 20% acknowledged a prognostic disclosure • Expressed preferences and documents ‘goals of care’ only agreed 1/3 time Heyland JAMA Int Med 2013

  10. Consequences of Intensification of Care at the End of Life • 7 academic centers from US • 332 patients with advanced cancer who died and their family caregivers • Patients asked, “have you and your doctor discussed any particular wishes you have about the care you would want to receive if you were dying?” • 123 (37%) reported have end of life discussion at baseline • median follow up 4.4 months after baseline Wright JAMA 2008;300:1665

  11. End of Life Discussions… …Associated with decreased intensity of care Wright JAMA 2008;300:1665

  12. plau • Background: • 30% of medical care is attributable to 5% of those who die in a year • About 1/3 of annual expenditures of those who die occurs in the last month • Most of these final costs are secondary to aggressive medical care in the last 30 days. • Patients with no EOL conversation much more likely to die in ICU, less likely to go to hospice • Last week of life medical expenses $2917 vs $1876 for those who did have a EOL conversation • Based on number of cancer deaths each year, if could increase ACP to 50% levels, would result in $76 million savings/year. Zhang Arch Intern Med 2009;169:480

  13. Summary Very elderly- it is plausible that poor communication and decision-making leads to overutilization of ICU resources and poor quality EOL care. To the extent that admission to ICU for an elderly patient requires a decision to be made, let’s improve clinical decision making!

  14. Purpose of Information Exchange Prognosis Values + Good Decision What do we know about the outcomes of the very elderly critically ill patient?

  15. REALISTIC-80What do we know about outcomes of Elderly in ICU European and US studies: ICU mortality 30-35% mortality 12 month mortality 60-70% mortality Severity of illness strongest predictor of short term survival Comorbidities strongest predictor of long term survival Significant comorbidities plus prolonged ICU stay=<5% survival Limited data on functional outcomes/QOL QOL studies in selected survivors Of survivors, functional status or QOL seems ‘reasonable’ Most studies old, single centered, using non-validated instruments of functional status No studies have comprehensively evaluated the determinants of long-term quality of life or functional recovery after critical illness in very elderly persons.

  16. Information Most Important to Patients Facing a Life-threatening Illness • Most Important • chances of surviving • resultant health state • Moderate Importance • Impact on family’s lives • Least Important • Length of hospital stay, • probability of institutionalization • amount of pain • ICUs, ventilators etc. More important for very elderly Heyland Chest 2006;130:419 and Lloyd CCM 200432:649

  17. Realities, Expectations and Attitudes to Life Support Technologies in Intensive Care forOctogenariansThe REALISTIC 80 study Funded by CIHR Conducted under the auspices of the CCCTG and CARENET

  18. REALISTIC-80Overall Design All 80+ admitted to participating ICU >24 hrs and had a family member present 610 Enrolled ICU 80+ Patients and their families 3,6,9,12 Month Outcomes Inclusion criteria:- >24 hrs in ICU - Family present Heyland Crit Care Med 2015; Palliative Med 2015; Intensive Care Med 2015 (in press)

  19. REALISTIC-80Research Questions-Patient Primary 1) What are the 12 month survival and HRQOL of patients admitted to ICU who are 80+ years old? Secondary 2) Which patient characteristics are associated with recovery from critical illness at 12 months? We defined ‘recovery’ from critical illness as being alive with SF-36 physical function score of at least 10 points and not 10 or more points below baseline at 12 months.

  20. REALISTIC-80Research Questions-Family 3) For non-surviving patients, what are the processes of care (descriptive)? 4) For non-surviving patients, what is the family satisfaction with EOL care, as measured using Family Satisfaction with ICU Care 24 (in ICU death) and the CANHELP Satisfaction instrument (in hospital)? 5) What are the values that influence decisions about goals of care for this patient population? 6) What is the quality of decision making about the goals of care for an 80+ patient?

  21. Kaplan-Meier Survival Curves of Study Population Compared to Age and Sex Matched Community Control Population.

  22. SF-36 Scores Among Survivors: Physical Functioning Domain Heyland ICM 2015 (in press)

  23. Recovery to Baseline Physical Function After Critical Illness Among Patients Aged 80 Years or Older Heyland ICM 2015 (in press)

  24. Logistic Regression Model Predicting Physical Recovery 12 months After ICU Admission Heyland ICM 2015 (in press)

  25. Clinical Prediction Rule

  26. REALISTIC-80Research Questions-Family 3) For non-surviving patients, what are the processes of care (descriptive)? 4) For non-surviving patients, what is the family satisfaction with EOL care, as measured using Family Satisfaction with ICU Care 24 (in ICU death) and the CANHELP Satisfaction instrument (in hospital)? 5) What are the values that influence decisions about goals of care for this patient population? 6) What is the quality of decision making about the goals of care for an 80+ patient?

  27. The Very Elderly Admitted to Intensive Care Unit: A quality finish ? • Of enrolled patients, 240 (39%) remained in ICU for 7 days or more; of these, 99 (41%) died in hospital. • Neither frailty nor advance directives had significant impact on processes of care (use or withhold/withdraw of life-sustaining treatments). Heyland CCM 2015

  28. Additional Family Member Perspectives • On average, interviews occurred 3 days after ICU admission • Family members reported that the “patient be comfortable and suffer as little as possible” was the most important value and “the belief that life should be preserved at all costs” was the least important value considered in making their treatment decisions. Heyland Palliative Medicine 2015

  29. Family Member Preferences • 57% reported that the doctor talked to them about being able to choose between treatment options for your family member in ICU. • 30.7% of family members had decisional conflict related to their treatment preference. • Decisional conflict was lower in family members who had talked to a doctor than those who had not. Heyland Palliative Medicine 2015

  30. Additional Family Member Perspectives • If family members’ stated preferred comfort measures • 83.7% of related patients received life-sustaining treatments; • 20.2% received one or more for more than 7 days • the time from ICU admission to death was on average 10.0 days amongst non-survivors. • Among non-survivors, time from ICU admission to death was longest in patients whose family members were ‘unsure’ of their treatment preferences (16.0 days vs. 10.0 days in comfort group vs. 12.0 days in life-sustaining treatments group; p=0.06). Heyland Palliative Medicine 2015

  31. Family Satisfaction with Critical Care(FS-ICU 24)

  32. If admitted to ICU Stay in ICU for a week or more Remain in hospital for a month or more 1/3 will die in hospital after a prolonged dying experience 1/3 will be discharged home 1/3 will be discharged to alternative location At 1 year Half patients will be dead 25% will have a good outcome (recovery to baseline) Narrative can be adapted to individuals with clinical prediction tool Conclusions (1)

  33. Baseline PF and Frailty Index are significant risk factors and consideration should be given to routinely measuring them in older patients admitted to ICU in addition to traditional measure describing the acute illness. There is incongruity between family members’ values and preferences for end of life care of their very elderly relatives, and the actual care received. Deficiencies in communication and decision-making may be associated with non-beneficial and prolonged use of life-sustaining treatments in very elderly critically ill patients, many of whom ultimately die. Conclusions (2)

  34. Where do we go from here?

  35. Elements to include Information leaflet on ‘how decisions are made’ and ‘your role’ and ‘how others cope’ Systematically eliciting patient/family values, preferences (including ACP/AD) Systematically offering non-curative, palliative care as a treatment option Systematically obtain information on key determinants to recovery (baseline PF, Frailty, comorbidities, etc.) Effectivenss of Multi-faceted Decision Support Intervention Provide this information to clinical team early in stay

  36. www.myicuguide.com

  37. A Quality Finsih? More needs to be done urgently to improve EOL care for very elderly (in Canada)!

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