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Evaluating Esophageal Varices Risk in HIV and HCV Patients Using Transient Elastometry

This study investigates the use of transient elastometry to assess the risk of esophageal varices in patients with HIV and HCV-related liver cirrhosis. It highlights the correlation between liver stiffness measurements and the presence of esophageal varices, providing insights into managing complications of cirrhosis. Results indicate that higher stiffness values (>36 kPa) are predictive of varices, while values <19 kPa suggest their absence. The findings affirm that, although transient elastometry is informative, it cannot replace gastroscopy for definitive diagnosis of varices.

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Evaluating Esophageal Varices Risk in HIV and HCV Patients Using Transient Elastometry

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  1. WEPDB 202: M.K. Mausolf1, M. Berger1, J. Breitkreutz1, J. Hartikainen1, U. Joppek1, H. Schulbin1, H. Stocker1, C. Traeder1, C. Weber1, T. Weipert1, K. Arastéh1, R. Weiss2, P. Ingiliz1 Institute(s): 1Vivantes Auguste-Viktoria-Klinikum Berlin, Gastroenterology and Infectious Diseases, Berlin, Germany, 2Hematology and Infectious Diseases, Bremen, Germany Evaluation of risk for esophageal varices by transient elastometry in patients with HIV and HCV infection and liver cirrhosis

  2. Complications of cirrhosis Transient elastometryas a tooltopredictcomplicationsofcirrhosis? 12 75 16 27 49 54 63 kPa EV grade 2 or 3 EV = 0 EAD HCC REV Chanteloup et al. AASLD Boston 2004

  3. Baseline characteristics of patients with Fibroscan >12.5 kPa1 and UGI (n=68) 1Castera L, et al. Gastroenterology 2005;128:343–350

  4. Significantly higher stiffness values in patients with varices p<0.01 36 19 Esophageal varices No varices

  5. Are values >36 kPa predictive for the presence of varices?

  6. Are values <19 kPa predictive for the absence of varices?

  7. Conclusions In cirrhotic patients (stiffness >12.5 kPa) transient elastometry indicates the presence of esophageal varices by higher values („the higher, the stiffer“) HCV infected and HIV/HCV coinfected patients with esophageal varices had median stiffness values of 36 kPa Fibroscan cannot replace gastroscopy for the diagnosis of varices Stiffness values <19 kPa strongly indicate the absence of esophageal varices

  8. Thank you for your attention!

  9. back-up slides

  10. ROC curve

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