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GUT PHYSIOLOGY Secretion 2

GUT PHYSIOLOGY Secretion 2. Dr. Jack Grider Rm 12-004 Sanger Hall 828-1853 jgrider@vcu.edu. 2009. Secretion: Gastroduodenal Junction. Secretions at the Gastroduodenal Junction. PANCREATIC: -Serous component: Water and bicarbonate ion -Protein component: pancreatic enzymes

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GUT PHYSIOLOGY Secretion 2

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  1. GUT PHYSIOLOGY Secretion 2 Dr. Jack Grider Rm 12-004 Sanger Hall 828-1853 jgrider@vcu.edu 2009

  2. Secretion: Gastroduodenal Junction

  3. Secretions at the Gastroduodenal Junction PANCREATIC: -Serous component: Water and bicarbonate ion -Protein component: pancreatic enzymes BILIARY -Serous component:Water and bicarbonate -Protein & other: bile and related secretions INTESTINAL: -Serous: Water and electrolyte

  4. Secretion:Pancreas Endocrine portion insulin, somatostain, glucagon, pancreatic polypeptide Exocrine portion water, electrolyte, enzymes

  5. Secretion: Exocrine Pancreas

  6. Secretion: Exocrine Pancreas: serous

  7. Secretion: Exocrine Pancreas: Protein • Storage in membrane bound zymogen granules • Storage as pro-enzymes • Trypsin inhibitor • Acidification of granule • Initial activation by enterokinase

  8. Secretion: Exocrine Pancreas Enterocyte Gut Lumen Pancreas

  9. Secretion: Exocrine Pancreas • Proteases (75%) • endo & exo • trypsin • Amylase • Lipases • Phospholipase cholesterol ester hydrolyase • Other enzymes • nucleases, elastases, etc • Other proteins • procolipase, trypsin inhibitor

  10. Secretion: Control Mechanisms Neural Hormonal major multiple hormones Interactions

  11. Secretion-Exocrine Pancreas: Neural Control

  12. Secretion:Hormonal control Secretin: water and Bicarbonate ion CCK: enzyme component -multiple stimulants of CCK -interactions with neural control PP & PYY: inhibitory control.

  13. Secretion: Exocrine PancreasRegulation by secretin

  14. Secretion: Exocrine Pancreas Regulation by CCK 6

  15. 7 Secretion: Exocrine PancreasRegulation by CCK

  16. Secretion: Exocrine PancreasPP & PYY

  17. Secretion: Exocrine Pancreas

  18. Secretion: Exocrine Pancreas

  19. Nutrient carriers Basolateral Na pump CFTR Nutrient Absorption (Carriers) CFTR Channel Basolateral Sodium Pump Secretion: Intestinal Goblet cells: mucus Duodenal Glands: water & bicarbonate ion Enterocyte -villus migration (6 days) -secretory cells in crytps -water and chloride ion -cystic fibrosis transmembrane regulator (CFTR channel) and ClC2 channel

  20. Secretion: Intestinal ClC2 Cholera Tx

  21. Secretion: Intestinal Enteric neurons from the submucosal plexus project all the way to the tip of the villus and innervate mucosal cells. Both sensory and motor neurons innervate the villus and crypt cells

  22. Secretion: Intestinal Enteric neurons from myenteric and submucosal plexus, and extrinsic neurons from the sympathetic and parasympathetic nervous system regulate secretomotor neurons (VIP & Ach) and secretory reflexes. SSt, Opioid and SNS inputs are inhibitory; cholinergic are excitatory.

  23. Secretion

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