1 / 1

Chronic Liver Disease

Chronic Liver Disease. Decompensated liver disease : Severe liver disease leading to encephalopathy, coagulopathy and jaundice Cirrhosis: Histological diagnosis . Functions of the liver Synthesis ( gluconeogenesis , glycogenesis , protein, cholesterol, coag factors, bile)

jud
Télécharger la présentation

Chronic Liver Disease

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Chronic Liver Disease Decompensated liver disease : Severe liver disease leading to encephalopathy, coagulopathy and jaundice Cirrhosis: Histological diagnosis Functions of the liver • Synthesis (gluconeogenesis, glycogenesis, protein, cholesterol, coag factors, bile) • Breakdown (drugs and toxins, glycogenolysis, bilirubin metabolism, ammonia) • Storage (glucose, vitamins, iron, copper) • Immunological function Gynaecomastia – decreased cholesterol synthesis, decreased androgen production in testes Encephalopathy – portal systemic shunting of nitrogenous gut products to brain Ascites – portal hypertension due to cirrhosis (increased hydrostatic pressure), low albumin (decreased oncotic pressure) Caput medusa, variceal bleeding – portal systemic shunting secondary to portal hypertension • Management of decompensated liver disease • Resuscitation, treat cause (N-acetyl cysteine in paracetamol OD) • Treat encephalopathy with lactulose/enemas (3 soft stools/day) • Glucose for hypoglycaemia • Vitamin K and FFP for coagulopathy • Antibiotics for SBP (>250 neutrophils/microL in ascitic tap, positive culture) • Chlordiazepoxide and Pabrinex for alcohol withdrawal if ALD • Gastric mucosa protection (omeprazole) • Nutrition

More Related