1 / 48

Singlet oxygen : From discovery to natural and biologically active product synthesis

Singlet oxygen : From discovery to natural and biologically active product synthesis. Literature Meeting. By Isabelle Bonnaventure. November, 8-15-22-28 th 2005. Presentation Outlook. Discovery of 1 O 2 and use as a reagent. Properties of 1 O 2. Generation of 1 O 2.

jui
Télécharger la présentation

Singlet oxygen : From discovery to natural and biologically active product synthesis

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Singlet oxygen:From discovery tonatural and biologically active product synthesis Literature Meeting By Isabelle Bonnaventure November, 8-15-22-28th 2005

  2. Presentation Outlook

  3. Discovery of 1O2 and use as a reagent

  4. Properties of 1O2

  5. Generation of 1O2

  6. Generation of 1O2

  7. Reaction Overview

  8. Ene reaction: Introduction

  9. Ene reaction: Introduction

  10. Ene reaction: Mechanism

  11. Ene reaction: Mechanism

  12. Ene reaction: Mechanism

  13. Ene reaction: “cis effect”

  14. Ene reaction: “cis effect”

  15. Ene reaction: “cis effect” in styrene derivatives

  16. Ene reaction: large group non-bonded effect

  17. Ene reaction: bulky subtituents

  18. Ene reaction: gem dimethyl/diethyl trisubstituted olefins

  19. Ene reaction: hydroxyl group directing effect

  20. Ene reaction: hydroxyl group directing effect

  21. Ene reaction: hydroxyl group directing effect

  22. Ene reaction: hydroxyl group directing effect

  23. Ene reaction: EWG at vinylic and allylic position

  24. Ene reaction: cyclic molecules

  25. Ene reaction: cyclic molecules

  26. Ene reaction: cyclic molecules

  27. Ene reaction: diastereoselectivity?

  28. Ene reaction: diastereoselectivity?

  29. Ene reaction: diastereoselectivity?

  30. Ene reaction: diastereoselectivity?

  31. Ene reaction: diastereoselectivity?

  32. Ene reaction: diastereoselectivity?

  33. Ene reaction: diastereoselectivity?

  34. Comparison with other a-oxidation methods

  35. [4+2] cycloaddition

  36. [2+2] cycloaddition

  37. [4+2], [2+2] cycloaddition or ene reaction ?

  38. [4+2], [2+2] cycloaddition or ene reaction ?

  39. [4+2], [2+2] cycloaddition or ene reaction ?

  40. [4+2], [2+2] cycloaddition or ene reaction ?

  41. [4+2], [2+2] cycloaddition or ene reaction ?

  42. Ene reaction: application

  43. Ene reaction: application

  44. [4+2] cycloaddition: application

  45. [4+2] cycloaddition: application

  46. [2+2] cycloaddition: application

  47. [2+2] cycloaddition: application

  48. Conclusion

More Related