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Understanding Alcohol Addiction: A Biochemical Perspective

Explore the biochemistry of alcohol, a common yet dangerous depressant that suppresses the central nervous system and metabolism. Learn about alcoholism's impact on genetics, culture, and health, including liver disease and Fetal Alcohol Syndrome. References included.

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Understanding Alcohol Addiction: A Biochemical Perspective

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  1. Alcohol Addiction By: Colleen Carter Biochemistry Spring 2012

  2. ALOCHOL • DEPRESSANT • MOST ABUSED DRUG • PSYCHOACTIVE • SUPPRESSES CENTRAL NERVOUS SYSTEM

  3. GENERAL METABOLISM • CONSUMPTION • ABSORPTION stomach and small intestine: gastrointestinal tract • DISTRIBUTION (DIFFUSION) concentration gradients • ELIMINATION through pores and urination

  4. Alcohol cannot be stored: Must be Oxidized !

  5. Alcoholism • Genetics • Culture • Psychologically • Mentally/Emotionally • Physical Potential liver disease Malnutrition Most common disease in the US Interferes with everyday life Liver reaches a saturation point Acetaldehyde accumulation Mitochondrial dysfunction

  6. Fetal Alcohol Syndrome • 5 out of 1,000 births • Indicatiors: stunted growth, CNS dysfunctions, these facial characterics

  7. References • Campbell, M. K., & Farrell, S. O. (2012). Biochemistry (7th ed.). Belmont, CA: Brooks/Cole. • National Institute on Alcohol Abuse and Alcoholism. http://www.niaaa.nih.gov/ Accessed on: May 7th, 2012 • National Center for Biotechnology Information. http://www.ncbi.nlm.nih.gov Accessed on: May 7th, 2012 • Svensson, S., Some, M., Lundsjö, A., Helander, A., Cronholm, T. and Höög, J.-O. (1999), Activities of human alcohol dehydrogenases in the metabolic pathways of ethanol and serotonin. European Journal of Biochemistry, 262: 324–329. doi: 10.1046/j.1432-1327.1999.00351.x

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