1 / 8

Mapping Genes and Determining the Allele Frequency of Genotype Through the Loci of Independent Variables

Mapping Genes and Determining the Allele Frequency of Genotype Through the Loci of Independent Variables. Vanessa Grieco Dr. Lin Seminar October 6, 2003. CKR5 and Delta 32. CKR5 is a chemokine (chemical factor released by immune cell, acts as natural suppressor

kamana
Télécharger la présentation

Mapping Genes and Determining the Allele Frequency of Genotype Through the Loci of Independent Variables

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Mapping Genes and Determining the Allele Frequency of Genotype Through the Loci of Independent Variables Vanessa Grieco Dr. Lin Seminar October 6, 2003

  2. CKR5 and Delta 32 • CKR5 is a chemokine (chemical factor released by immune cell, acts as natural suppressor • CKR5 and receptor are proteins • If Delta 32 base pair deleted then a frame shift of amino acid occurs

  3. 32 magic number Addition or deletion not divisible by three will cause a frame shift. Codons are triplet code which consists of three nucleotides 33 has no frame shift

  4. Recessive versus Dominant • Recessive restriction is expressed with 2 copies • Dominate phenotype with only 1 allele • Allele is and alternative form of a gene • Homozygous (same alleles) • Heterozygous (different alleles)

  5. Mapping of CKR genes Dean et.al. 1996, Science, 273:1856-1862

  6. Genetic Markers and HIV-1 Infection Dean et.al. 1996, Science, 273:1856-1862, Fig.2

  7. Results • CKR5 was the only loci that displayed a significant distortion • No difference in allele frequencies of CKR5 between HIV-1-infected and HIV-1 antibody negative individuals • HIV negative individuals have recessive restriction • Heterozygous progresses disease later if it has one allele Delta 32

  8. Work Citied • Dean M. et.al.Genetic Restriction of HIV-1 Infection and Progression to AIDS by a Deletion Allele of the CKR5 Structural Gene. Science (Sept 27 1996) 273:1858-1862 • O'Brien Stephen J.and Dean M. The Search of AIDS-Resistance Gene. Scientific American, September, 1997  • http://www.projinf.org/fs/dp-CKR5_Fusin.html

More Related