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Excitation Excitation-contraction coupling Contraction Regulation of contraction

Excitation Excitation-contraction coupling Contraction Regulation of contraction Metabolism of contraction Smooth muscle. Excitation. Excitation-contraction coupling. dihydropyridine. ryanodine. Andrew HUXLEY 1953. TITIN. actinin. ACTIN.

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Excitation Excitation-contraction coupling Contraction Regulation of contraction

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Presentation Transcript

  1. Excitation • Excitation-contraction coupling • Contraction • Regulation of contraction • Metabolism of contraction • Smooth muscle

  2. Excitation

  3. Excitation-contraction coupling

  4. dihydropyridine ryanodine

  5. Andrew HUXLEY 1953 TITIN actinin

  6. ACTIN

  7. Actin together with Mg a ATP se binds to myosin, When tropomyosin is added binding releases In presence of Ca the efekt of troponin on tropomyosin complex on A - M interaction disapears Ca binds to troponin C – binding sites of actin arc uncovered

  8. MYOSIN

  9. CONTRACTION

  10. Regulation of contraction

  11. 2 um

  12. Force gradation: • Recruitment (spacial sumation) • temporal sumation tetany

  13. Metabolism of contraction

  14. min 10 sec MYOGLOBIN

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