1 / 1

Table 2S

0.023. 0.023. 0.23. 0.23. 2.3. 2.3. 23 c. 23. 3.84. 20.8. 104. 1.3. 1.8. 4.2. 1. 1.1. 0.7. 1.2. 1.3. 1.18. Table 2S. 5-Me-Tetrahydrofolate (5-MeTHF). Folic acid (FA). Tetrahydrofolate (THF). IC 50 s (nM) in physiological folate (5-Me-THF 0.023 µM). IC 50 s (nM) in

kelli
Télécharger la présentation

Table 2S

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. 0.023 0.023 0.23 0.23 2.3 2.3 23 c 23 3.84 20.8 104 1.3 1.8 4.2 1 1.1 0.7 1.2 1.3 1.18 Table 2S 5-Me-Tetrahydrofolate (5-MeTHF) Folic acid (FA) Tetrahydrofolate (THF) IC50s (nM) in physiological folate (5-Me-THF 0.023 µM) IC50s (nM) in physiological folate (FA 0.023 µM) Increased factor of IC50sa in presence of 0.23, 2.3 and 23 µM FA IC50s (nM) in physiological folate (THF 0.023 µM) Increased factor of IC50a in presence of 0.23, 2.3 and 23 µM of THF Increased factor of IC50sa in presence of 0.23, 2.3 and 23 µM of THF 23 0.023 0.23 2.3 0.31+0 PM b 0.3+0.1 5.6 23.3 33.5 0.26+0 1.3 1.4 ND 0.22+0 1.7 2.52 3.2 0.23+0 0.16+0 0.98 1.1 ND CCG b 36.5+3.5 0.91 1.3 28.5+3.5 1.01 0.97 ND MTX 0.94 31.0+1 47.81+7.2 0.98 1.25 ND AMP 1.2 51.2+1.8 46.4+9.8 0.87 1.4 TMX ND 3.95+0.8 1.01 1.3 1.7 2.6+0.8 0.97 1.0 1.2 3.1+0.11 1.1 0.8 aIncrease factor of IC50s represents the ratio of IC50 in physiological folate condition versus the IC50 in presence of high folate condition. bIncrease value of PM and CCG in bold are all statistically significant (p<0.05) c concentration of 23 uM of 5-Me-THF was inhibitory

More Related