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Relationship Between PHGDH Suppression and Glutamine Anaplerosis Deficiency

Inhibition of PHGDH leads to reduced glutamine conversion to αKG, impacting cellular metabolism. This study sheds light on the importance of PHGDH in maintaining normal anaplerosis processes crucial for cell function.

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Relationship Between PHGDH Suppression and Glutamine Anaplerosis Deficiency

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  1. Suppression of PHGDH results in a deficiency in anaplerosis of glutamine to aKG. R Possemato et al.Nature000, 1-5 (2011) doi:10.1038/nature10350 Note: This figure is from a near-final version AOP and may change prior to final publication in print/online

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