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MESENCHYMAL STEM CELL EXOSOMES

A leading exosome biotechnology laboratory specializing in the production of perinatal mesenchymal stem cell-derived (MSC) exosome products for scientific and clinical research.

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MESENCHYMAL STEM CELL EXOSOMES

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  1. MESENCHYMAL STEM CELL EXOSOMES Kimera Labs

  2. Mesenchymal stem cell exosomes are produced by connective tissue stem cells, skin, hair, bone, muscle, cartilage, and other connective tissues. Exosomes discovered in adult bone marrow, largely hematopoietic stem cell exosomes, differ significantly from exosomes found in amniotic fluid, essentially maternal epithelial cell exosomes. Thus, many extraordinary MSC exosome therapeutic advantages associated with stem cell therapy are the unique capacity to promote connective tissue formation.

  3. MSC-derived exosomes have the versatility and aptitude to interact with various cell types both locally and remotely to elicit appropriate cellular responses. At Kimera labs, a world-class exosome biotechnology research lab, we target housekeeping activities with their released MSC exosomes to restore tissue homeostasis and allow cells within the tissue to recover, repair and renew.

  4. BENEFITS The number and function of MSC exosomes in our tissues decreases as we become older. Compared to prenatal MSCs, aged autologous progenitor cells produce roughly 30% more cytokines and have considerably different miRNAs. Because of this considerable alteration in the secretome, perinatal MSC Exosomes have a significant advantage over exosomes from aged autologous or allogeneic progenitor cells.

  5. Increase collagen extracellular matrix synthesis and deposition stimulate fibroblast proliferation and migration promote angiogenesis in acute and chronic wounds Reduce inflammation and the immune system's response Reduce scarring by controlling tissue remodeling. In the growing phase, increase the number of hair follicles Rejuvenate the hair follicle's dermal papilla cells. ● ● ● ● ● ● ●

  6. PROPERTIES 1. Anti-Inflammatory Properties- Anti-inflammatory proteins are upregulated, whereas inflammatory proteins are downregulated. MSC-derived exosomes can help to decrease inflammation. Many autoimmune inflammatory and degenerative diseases, as well as scarring, have this mechanism at their core.

  7. 2. Regenerative- By stimulating the proliferation and migration of cells such as fibroblasts, endothelial cells, keratinocytes, and specific endogenous progenitor cells involved in healing damaged tissues, MSC exosomes improve damaged tissue survival and speed wound healing and skin regeneration, and reduce scarring. 3. Tissue Remodelling and Regeneration- MSC-derived exosomes have been found to minimize apoptosis (programmed cell death), perhaps resulting in minor tissue damage resulting from disease or injury. MSC Exosomes can improve tissue remodeling by supporting a standard collagen fiber lattice structure, resulting in less scarring and more natural healing.

  8. Compared to auto-MSCs, there have been fewer studies on allogeneic mesenchymal stem cell applications recently, but we at Kimera are determined to take this invention as further as possible.

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