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Metabolism of Buprenorphine During Pregnancy and Postpartum

This study analyzes buprenorphine metabolites in pregnant women to understand changes during trimesters and postpartum. Significant differences in metabolite ratios were found.

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Metabolism of Buprenorphine During Pregnancy and Postpartum

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  1. 1 2 A 1.5 1 0.5 0.5 0 0 1 2 B 1.5 0.5 1 0.5 0 0 2 C 1 1.5 1 0.5 0.5 0 0 A B C D E F G H I A B C D E F G H I Participant Participant Norbuprenorphine to Norbuprenorphine Glucuroide Ratio Bupprenorphine Glucuronide to Norbuprenorphine Glucuronide Ratio Supplemental Figure 1: Buprenorphine glucuronide (BUP-Gluc) to norbuprenorphine glucuronide (NBUP-Gluc) (Left) and norbuprenorphine (NBUP) to NBUP-Gluf (Right) ratios for nine participants during the A) second trimester, B) third-trimester and C) post-partum. At p<0.05 the following statistically significant differences were identified: For BUP-Gluc to NBUP-Gluc, participants A and G: 3rd trimester>post-partum; participants C and D: 2nd trimester<3rd trimester, participant B: 2nd<PP; participant H: 3rd<PP. For NBUP to NBUP-Gluc, participant E: 2nd trimester<3rd trimester and 3rd trimester<PP; participant H: 2nd and 3rd trimester<PP

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