1 / 21

Regulating the cell cycle

Honors Biology Chapter10 Section 3 SC B-2.7: Summarize how cell regulation controls & coordinates cell growth & division & allows cells to respond to the environment, and recognize the consequences of uncontrolled cell division. Regulating the cell cycle. Essential Question.

kylene
Télécharger la présentation

Regulating the cell cycle

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Honors Biology Chapter10 Section 3 SC B-2.7: Summarize how cell regulation controls & coordinates cell growth & division & allows cells to respond to the environment, and recognize the consequences of uncontrolled cell division Regulating the cell cycle

  2. Essential Question • How does cancer happen?

  3. Cell Cultures • Cells in a petri dish with appropriate nutrients will continue to grow until they come in contact with other cells: called • Contact Inhibition

  4. Contact Inhibition • similar controls in body • occurs in wound healing

  5. Cell Cycle & Its Regulators

  6. Cell Cycle Regulators: Cyclins • regulators are cell proteins (cyclins) • regulate timing of cell cycle in eukaryotic cells • dozens other proteins since discovered • Internal Regulators • External Regulators

  7. Internal Regulators • proteins that respond to events inside the cell • allow cell cycle to proceed once certain processes have been completed inside cell

  8. External Regulators • proteins that respond to events outside cell • direct rate of cell division • most important ones: • Growth Factors • important in embryonic development • also used in wound healing

  9. Uncontrolled Cell Division Cancer • cancer: disorder in which some of an organisms cells have lost ability to control growth • Cancer cells do not respond to signals that regulate cell division

  10. Cancer Cells have Loss of Contact Inhibition

  11. Causes of Loss of Control??? • appears to have many causes: • carcinogens • some affect internal regulators, some external regulators • defect in gene p53

  12. Carcinogens • Nicotine • Viruses • Hepatitis • Human Papilloma Virus (HPV) • Bovine Papilloma Virus • Tobacco Virus • Radiation

  13. Cancer Cells

  14. Skin Cells

  15. Stomach Cells

  16. HeLa Cells • Henrietta Lacks died of cervical cancer in Johns Hopkins Hospital, Baltimore, MD in 1950’s • Biopsies of her cervix taken to researchers @Johns Hopkins where they were cultured &they are still growing!

  17. HeLa Cells • used in multiple medical areas: • development of Polio Vaccine • trip to the moon : What is the effect of weightlessness on rate of cell growth/division ? • cell cloning • gene mapping • hybrid cell lines

  18. HeLa Cells

More Related