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Bone metabolism

Bone metabolism. Bone is constantly remodelling Bone resorption = bone formation Why remodelling is necessary? To withstand changing environment To cope with workload To repair damage caused by recurrent microtraumas BONE METABOLISM Osteoclasts and Osteoblasts Osteocytes

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Bone metabolism

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  1. Bone metabolism • Bone is constantly remodelling • Bone resorption= bone formation • Why remodelling is necessary? • To withstand changing environment • To cope with workload • To repair damage caused by recurrent microtraumas BONE METABOLISM Osteoclasts and Osteoblasts Osteocytes Encased osteoblasts which are connected to each other by long cellular processes forming a network connected by gap junctions.

  2. Biochemical markers • a) enzyme activity markers of • bone formation (connected with osteoblast activity) • bone resorption (connected with osteoclast activity) • b) bone matrix proteins and resorption products of organic skeletal matrix, which are released into circulation during bone formation and resorption; and • c) inorganic skeletal matrix markers • Calcium • phosphorus

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