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ECG in Toxicology:

ECG in Toxicology:. What are we looking for?. Geoff Isbister Clinical Toxicologist Calvary Mater Newcastle. Myocardial cell action potential. ECG. 1. +20mV. 2. 3. 0. 4. -90mV. Na +. IC. ATPase. EC. K +. K +. K +. Ca + +. Na +. K +.

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ECG in Toxicology:

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  1. ECG in Toxicology: What are we looking for? Geoff Isbister Clinical Toxicologist Calvary Mater Newcastle

  2. Myocardial cell action potential ECG 1 +20mV 2 3 0 4 -90mV Na + IC ATPase EC K+ K+ K+ Ca + + Na + K + • Quinidine–like drugs (TCAs, chloroquine, antipsychotics, • antiarrhythmics, antihistamines, etc) block Na+ & K+ channels

  3. Myocardial cell action potential ECG 1 +20mV 2 3 0 4 -90mV Na + IC ATPase EC K+ K+ K+ Ca + + Na + K + • Quinidine–like drugs (TCAs, chloroquine, antipsychotics, • antiarrhythmics, antihistamines, etc) block Na+ & K+ channels

  4. Myocardial cell action potential ECG 1 +20mV 2 3 0 4 -90mV Na + IC ATPase EC K+ K+ K+ Ca + + Na + K +

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