Distributor Meeting MEDICA November, 2009

1. Dr. Ariel Weisz R&D Department Metrolab, Argentina Distributor Meeting MEDICA November, 2009

2. Metrolabis a company which designs and manufactures • Clinical Chemistry Analyzers with its own technology. • + reliable instruments to the global market • + easy of use • + effective after-sale service • + competitive prices

3. Clinical Chemistry Analyzers The Principle: Spectrophotometry

4. Beer-Lambert Law Absorbance concentration T = P / P0 A = log10(P0 / P) A = elbc el: molar absorbtivity c: molar concentration

5. Colorimetry Reagents Samples Reactions Mix Incubation (37°C) Measure

6. Double beam photometer beam splitter reaction cuvettes sampledetector filter lamp S R referencedetector A = log(R/S)

7. Dual photometer reference detector R Back sample detector beamsplitters filter SB lamp AF = log(R/SF) AB = log(R/SB) SF Front sample detector

8. Clinical Chemistry Analyzers Applications and Measuring Methods

9. One Reagent End Point A Metabolites Albumin Glucose Cholesterol Uric acid Triglycerides Total proteins Absorbance B R1+S Time Measure = A - B

10. Two-Reagent End Point A2 Bilirubin IgA, IgG, IgM LDL, HDL Phosphorous A1 Absorbance B2 B1 R1+S R2 Time Measure = (A2-A1) – (B2-B1)

11. Fixed Point Kinetics A2 ALP Creatinine Fructusamine Urea A1 Absorbance B2 B1 R1+S Time Measure = (A2-A1) – (B2-B1)

12. Kinetics An Enzymes Amylase CK, CPK GGT GOT GPT A1 Absorbance Bn B1 R1+S Time Measure = rateA – rateB

13. Clinical Chemistry Analyzers METROLAB Instruments

14. //Metrolab history 305 330 1600 DR 1600 DRK 315 1600 PLUS 2100 2300 4000 1985 1990 1995 2000 2005

15. //Current Line - Main Instruments 60-250+ patients/day 600 test/hr 600 test/hr 20-60+ patients/day 280 test/hr M4000 400 10-40 patients/day 240 test/hr semiautomatic M2300v4 200 M2300GL M1600DRv3 small labs veterinary medium labs big labs / hospitals

16. Clinical Chemistry Analyzers METROLAB 4000

17. Troughput: 550 test/hr without ISE • 600 test/hr single reagent • 450 test/hr double reagent • 720 test/hr with ISE

18. Split reagent trays for effective carryover and interference control Methods are distributed, at operator’s will between two trays. In this way, interfering methods never come into contact in the same cuvette

19. Continuous sample load with coded sectors Positions can be assigned to normal samples or STATS, Handling priorities accordingly

20. Positive BCR identification of samples, reagents and sectors • Coded sectors for instantaneous load • Any coding system for samples • Coded reagents and optional closed system • Open channel support

21. Optional ISE module: Na+, K+, Cl- • Direct serum readings • Indirect urine readings (dilution 1:10) • Integrated pack for simple operation • Automatic electrode conditioning

22. Quick keys menu Test in progress General status bar User friendly software with different access levels Menu bar Current activity and summary Main operation control tool bar Requests to operator bar Reagents status report Messages list

23. Mixer in probe • High efficiency mixing guarantees reliable data in double reagent systems and viscous media • Shake time can be programmed for every method

24. 72 on board cooled single reagents Full size 70 ml Outer 30 ml R1 40ml R2 30 ml

25. LIS Interface Connection - Customized Reports PC Monitor LIS Metrolab 4000 PC ASTM Standard serial connection Monitor Data Management System

26. Low Water Consumption 4 mL / test

27. //Current Line - Main Instruments 60-250+ patients/day 600 test/hr 600 test/hr 20-60+ patients/day 280 test/hr M4000 400 10-40 patients/day 240 test/hr semiautomatic M2300v4 200 M2300GL M1600DRv3 small labs veterinary medium labs big labs / hospitals

28. Clinical Chemistry Analyzers METROLAB 2300 PLUS version 4

29. Version 4 FULLY AUTOMATIC RANDOM ACCESS CLINICAL ANALYZER • End Point • Kinetics • Immunoturbidimetry • Coagulation • ISE • Barcode: Samples & Reagents • Automatic Sample Dilution • Mixer on Probe • Quality Control

30. Version 4 Samples • 48 positions for primary tubes, tubes 75 to 100 mm (Ø 13 mm), accepts microtainers. • Positive BCR identification of samples • Test request through LIS

31. Version 4 Reagents • 48 positions cooled reagent • Bar code for reagents • Dual reagent capability • 50, 30 and 20 mL containers • 24 hours non stop cooling

32. Version 4 Cuvette washing system • 4-Step washing station • Automatic cuvette check • 6 mm light path PMMA cuvettes

33. Version 4 Multifunction probe • Mixer on probe • Collision detector • Capacitive liquid level detection • Effective probe washing

34. Version 4 Optical system • Double beam • 9 interference filters: 340, 405, 505, 550, 590, 650, 700 and 767 nm. • Optional filters available (380 and 620 nm )

35. Version 4 Software • User friendly • Flexible • Designed for the clinical analyst • Continuous upgrade meeting your requirements

36. Version 4 Easy service • Open cabinet with only 4 screws • Calibration through PC

37. //Current Line - Main Instruments 60-250+ patients/day 600 test/hr 600 test/hr 20-60+ patients/day 280 test/hr M4000 400 10-40 patients/day 240 test/hr semiautomatic M2300v4 200 M2300GL M1600DRv3 small labs veterinary medium labs big labs / hospitals

38. Clinical Chemistry Analyzers METROLAB 2300 GL

39. METROLAB 2300 GL Easy service • Calibration through PC • No cooling system • No washing system • No BCR • No ISE

40. METROLAB 2300 GL Quick cuvette load • Simple and Fast • Double tray • One tray in use (80 cuvettes) • Preloaded tray ready to use

41. Clinical Chemistry Analyzers Common Hints

42. Clinical Chemistry Analyzers Common Hints • Pipetting principle • Semi-disposable plastic cuvettes • Low water consumption • Probe technology • Line style

43. Clinical Chemistry Analyzers Common Hints • Proprietary Technology • Proprietary software • Open or closed customized systems • Dedicated after-sales service

44. Clinical Chemistry Analyzers Next Steps… • Modular electronics • Reduce manufacturing costs • Standardization

45. Clinical Chemistry Analyzers Thank you for your attention !!!