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HEART TRANSPLANTATION

This study examines the age distribution and actuarial survival rates of pediatric heart transplant recipients from 1982 to 2001. Through comprehensive data analysis, key findings include variations in survival rates by age at transplantation, risk factors impacting one-year and five-year mortality, and the investigation of diagnoses leading to transplantation. The study highlights significant differences in survival outcomes depending on age groups, underscoring the necessity for tailored approaches in pediatric heart transplantation.

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HEART TRANSPLANTATION

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  1. HEART TRANSPLANTATION Pediatric Recipients

  2. AGE DISTRIBUTION OF PEDIATRIC HEART RECIPIENTS(1982-2001)

  3. AGE DISTRIBUTION FOR DONORS OF PEDIATRIC HEART RECIPIENTS(1982-2001)

  4. 385 378 372 365 363 364 349 350 356 326 340 319 254 193 130 109 75 42 11 9 AGE DISTRIBUTION OF PEDIATRIC HEART RECIPIENTSBy Year of Transplant Number of Transplants * Numbers may be low due to delayed reporting.

  5. NUMBER OF CENTERS REPORTING PEDIATRIC HEART TRANSPLANTS * Numbers may be low due to delayed reporting

  6. DIAGNOSIS IN PEDIATRIC HEART TRANSPLANT RECIPIENTS (Age: < 1 Year)

  7. DIAGNOSIS IN PEDIATRIC HEART TRANSPLANT RECIPIENTS(Age: 1-10 Years)

  8. DIAGNOSIS IN PEDIATRIC HEART TRANSPLANT RECIPIENTS(Age: 11-17 Years)

  9. PEDIATRIC HEART TRANSPLANTATIONActuarial Survival (1982-2001) <1 year vs. 1-10 years: p = 0.0005 <1 year vs. 11-17 years: p = 0.001

  10. PEDIATRIC HEART TRANSPLANTATIONConditional Actuarial Survival(1982-2001) Both comparisons with 11-17 years significant at p < 0.0001

  11. PEDIATRIC HEART TRANSPLANTATIONConditional Actuarial Survival for Recent Era (1998-2001) Comparison of <1 vs. 11-17 years significant at p = 0.01

  12. PEDIATRIC HEART TRANSPLANTATIONActuarial Survival by Era (1982-2001) Survival (%) All comparisons with 1998-2001 are significant at p < 0.0001 Comparison of 1982-1987 vs. 1988-1992 was significant at p = 0.003 Comparison of 1982-1987 vs. 1993-1997 was significant at p < 0.0001

  13. PEDIATRIC HEART TRANSPLANTATION Actuarial Survival by Age GroupFor Diagnosis = Cardiomyopathy(1988-2001) Survival (%) No comparisons were statistically significant.

  14. PEDIATRIC HEART TRANSPLANTATION Actuarial Survival By Age GroupFor Diagnosis = Congenital Disease(1988-2001) Survival (%) Comparison of <1 vs. 11-17 was significant at p = 0.01

  15. PEDIATRIC HEART TRANSPLANTS (1996-2001)Risk Factors For 1 Year MortalityIn Descending Order of Magnitude N=1,554

  16. PEDIATRIC HEART TRANSPLANTS (1996-2001)Risk Factors for 1 Year MortalityContinuous Factors N=1,554

  17. PEDIATRIC HEART TRANSPLANTS (1996-2001) Factors Not Significant for 1 Year Mortality

  18. PEDIATRIC HEART TRANSPLANTS (April 1994 - December 1996)Risk Factors For 5 Year MortalityIn Descending Order of Magnitude N=937

  19. PEDIATRIC HEART TRANSPLANTS (April 1994 - December 1996)Risk Factors For 5 Year MortalityContinuous Factors N=937

  20. PEDIATRIC HEART TRANSPLANTS(April 1994 - December 1996)Factors Not Significant for 5 Year Mortality

  21. PEDIATRIC HEART TRANSPLANTS (April 1994 - December 1996)Risk Factors for 5 Year Mortality Conditional on Survival to 1 YearIn Descending Order of Magnitude N=728

  22. PEDIATRIC HEART RECIPIENTS Functional Status (April 1994-December 2001)

  23. PEDIATRIC HEART RECIPIENTS Rehospitalization Post-transplant(April 1994 - December 2001)

  24. PEDIATRIC HEART RECIPIENTSInduction ImmunosuppressionFor follow-ups between October 1999 and December 2001

  25. PEDIATRIC HEART RECIPIENTSMaintenance Immunosuppression at Any Time During Follow-up PeriodFor follow-ups between October 1999 and December 2001

  26. PEDIATRIC HEART RECIPIENTSMaintenance Immunosuppression at Time of Follow-upFor follow-ups between October 1999 and December 2001

  27. PEDIATRIC HEART RECIPIENTSMaintenance Immunosuppression at Time of Follow-upFor follow-ups between October 1999 and December 2001 1 Year Follow-up (N=429) 5 Year Follow-up (N = 303)

  28. PEDIATRIC HEART RECIPIENTSMaintenance Immunosuppression at Time of Follow-upFor follow-ups between October 1999 and December 2001

  29. POST-HEART TRANSPLANT MORBIDITY FOR PEDIATRICSCumulative Incidence for Survivors(April 1994-December 2001)

  30. Freedom from CAV For Pediatric Heart Recipients(April 1994-December 2000)

  31. Freedom from Renal Dysfunction*For Pediatric Heart Recipients(April 1994-December 2000) * Renal dysfunction = Creatinine > 2.5 mg/dl, dialysis or renal transplant

  32. MALIGNANCY POST-HEART TRANSPLANTATION FOR PEDIATRICSCumulative Incidence for Survivors(April 1994-December 2001)

  33. Freedom from MalignancyFor Pediatric Heart Recipients(April 1994-December 2000)

  34. PEDIATRIC HEART TRANSPLANTATIONActuarial Survival Based on Prednisone Use p = 0.005

  35. PEDIATRIC HEART TRANSPLANTATIONActuarial Survival Based on Rejection within 1st Year P = 0.09

  36. PEDIATRIC HEART RECIPIENTSRelationship of Prednisone Use and CADTransplants: April 1994 – December 1999 p = 0.4 p = 0.06

  37. PEDIATRIC HEART RECIPIENTSRelationship of Rejection and CADTransplants: April 1994 – December 1999 p = 0.02 p = 0.09

  38. PEDIATRIC HEART RECIPIENTS Incidence of Hypertension between 1 and 3 Years

  39. PEDIATRIC HEART RECIPIENTS Incidence of Hypertension by 3 Years

  40. PEDIATRIC HEART RECIPIENTSGrowth Following Transplantation: HeightStratified by Prednisone Use at Discharge and at 1 Year

  41. PEDIATRIC HEART RECIPIENTSGrowth Following Transplantation: WeightStratified by Prednisone Use at Discharge and at 1 Year

  42. PEDIATRIC HEART RECIPIENTS: Time of Death(1988-2001)

  43. PEDIATRIC HEART TRANSPLANT RECIPIENTS: Cause of Death(1982-2001) Cause of Death (%) Timing of Death

  44. PEDIATRIC HEART TRANSPLANTS RECIPIENTS: CAUSE OF DEATH BY ERA: Deaths in 0-30 Days

  45. PEDIATRIC HEART TRANSPLANTS RECIPIENTS: CAUSE OF DEATH BY ERA: Deaths in 31 Days - 1 Year

  46. PEDIATRIC HEART TRANSPLANTS RECIPIENTS: CAUSE OF DEATH BY ERA: Deaths in >1 Year - 3 Years

  47. PEDIATRIC HEART TRANSPLANTS RECIPIENTS:CAUSE OF DEATH BY ERA: Deaths in >3 Years - 5 Years

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