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HEART TRANSPLANTATION

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190 diapositives · 2.2K Views · Jul 17, 2014

HEART TRANSPLANTATION. Pediatric Recipients. 2013. JHLT. 2013 Oct; 32(10): 979-988. Donor, Recipient and Center Characteristics. 2013. JHLT. 2013 Oct; 32(10): 979-988. Pediatric Heart Transplants Number of Centers Reporting Transplants. 2013. JHLT. 2013 Oct; 32(10): 979-988.

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  1. HEART TRANSPLANTATION Pediatric Recipients 2013 JHLT. 2013 Oct; 32(10): 979-988

  2. Donor, Recipient and Center Characteristics 2013 JHLT. 2013 Oct; 32(10): 979-988

  3. Pediatric Heart TransplantsNumber of Centers Reporting Transplants 2013 JHLT. 2013 Oct; 32(10): 979-988

  4. Pediatric Heart TransplantsNumber of Centers by Center Volume(Transplants: January 2000 – June 2012) 2013 JHLT. 2013 Oct; 32(10): 979-988

  5. Pediatric Heart TransplantsDistribution of Transplants by Center Volume(Transplants: January 2000 – June 2012) 2013 JHLT. 2013 Oct; 32(10): 979-988

  6. Pediatric Heart TransplantsAge Distribution by Center Volume(Transplants: January 2000 – June 2012) 2013 JHLT. 2013 Oct; 32(10): 979-988

  7. Pediatric Heart Transplants Distribution of Transplants by Location and Average Center Volume (Transplants: January 2000 – June 2012) 2013 JHLT. 2013 Oct; 32(10): 979-988

  8. Pediatric Heart TransplantsRecipient Age Distribution (Transplants: January 2000 - June 2012) 2013 JHLT. 2013 Oct; 32(10): 979-988

  9. Pediatric Heart TransplantsRecipient Age Distribution by Year of Transplant NOTE: This figure includes only the heart transplants that are reported to the ISHLT Transplant Registry. As such, this should not be construed as evidence that the number of hearts transplanted worldwide has increased and/or decreased in recent years. 2013 JHLT. 2013 Oct; 32(10): 979-988

  10. Pediatric Heart TransplantsRecipient Age Distribution by Location (Transplants: January 2000 – June 2012) 2013 JHLT. 2013 Oct; 32(10): 979-988

  11. Pediatric Heart TransplantsDonor Age Distribution (Transplants: January 2000 – June 2012) 2013 JHLT. 2013 Oct; 32(10): 979-988

  12. Pediatric Heart TransplantsDonor and Recipient Age(Transplants: January 2000 – June 2012) 2013 JHLT. 2013 Oct; 32(10): 979-988

  13. Pediatric Heart TransplantsDistribution of Transplants by Donor/Recipient Age(Transplants: January 2000 – June 2012) 2013 JHLT. 2013 Oct; 32(10): 979-988

  14. Pediatric Heart TransplantsDonor Age Distribution by Location (Transplants: January 2000 – June 2012) 2013 JHLT. 2013 Oct; 32(10): 979-988

  15. Pediatric Heart TransplantsDistribution of Transplants by Donor/Recipient Weight Ratio(Transplants: January 2000 – June 2012) 2013 JHLT. 2013 Oct; 32(10): 979-988

  16. Pediatric Heart TransplantsRecipient Diagnosis (Age: < 1 Year) 2013 JHLT. 2013 Oct; 32(10): 979-988

  17. Pediatric Heart TransplantsRecipient Diagnosis (Age: 1-5 Years) 2013 JHLT. 2013 Oct; 32(10): 979-988

  18. Pediatric Heart TransplantsRecipient Diagnosis (Age: 6-10 Years) 2013 JHLT. 2013 Oct; 32(10): 979-988

  19. Pediatric Heart TransplantsRecipient Diagnosis (Age: 11-17 Years) 2013 JHLT. 2013 Oct; 32(10): 979-988

  20. Pediatric Heart TransplantsDiagnosis Distribution By Location (Transplants: January 2000 – June 2012) 2013 JHLT. 2013 Oct; 32(10): 979-988

  21. Pediatric Heart Transplants% of Patients Bridged with Mechanical Circulatory Support* by Year (Transplants: January 2005 – December 2011) 2013 * LVAD, RVAD, TAH, ECMO JHLT. 2013 Oct; 32(10): 979-988

  22. Pediatric Heart Transplants% of Patients Bridged with Mechanical Circulatory Support* (Transplants: July 2004 – June 2012) 2013 * LVAD, RVAD, TAH, ECMO JHLT. 2013 Oct; 32(10): 979-988

  23. Pediatric Heart Transplants% of Patients Bridged with Mechanical Circulatory Support* by Age Group (Transplants: July 2004 – June 2012) 2013 * LVAD, RVAD, TAH, ECMO JHLT. 2013 Oct; 32(10): 979-988

  24. Pediatric Heart TransplantsPRA Distribution by Year(Transplants: January 2005 – December 2011) 2013 JHLT. 2013 Oct; 32(10): 979-988

  25. Pediatric Heart TransplantsPRA Distribution by Age Group (Transplants: July 2004 – June 2012) 2013 p-value = 0.0011 JHLT. 2013 Oct; 32(10): 979-988

  26. Post Transplant:Survival and Other Outcomes 2013 JHLT. 2013 Oct; 32(10): 979-988

  27. Pediatric Heart TransplantsKaplan-Meier Survival (Transplants: January 1982 – June 2011) 6-10 vs. 11-17: p = 0.0192 No other pair-wise comparisons were significant at p < 0.05 2013 JHLT. 2013 Oct; 32(10): 979-988

  28. Pediatric Heart TransplantsKaplan-Meier Survival Conditional on Survival to 1 Year (Transplants: January 1982 – June 2011) All pair-wise comparisons were significant at p < 0.05 except <1 vs. 1-5 and 1-5 vs. 6-10 2013 JHLT. 2013 Oct; 32(10): 979-988

  29. Pediatric Heart TransplantsKaplan-Meier Survival Conditional on Survival to 5 Years (Transplants: January 1982 – June 2007) All pair-wise comparisons were significant at p < 0.05 except 6-10 vs. 11-17 2013 JHLT. 2013 Oct; 32(10): 979-988

  30. Pediatric Heart TransplantsKaplan-Meier Survival Conditional on Survival to 10 Years (Transplants: January 1982 – June 2002) All pair-wise comparisons with <1 were significant at p < 0.0001. No other pair-wise comparisons were significant at p < 0.05. 2013 JHLT. 2013 Oct; 32(10): 979-988

  31. Pediatric Heart TransplantsKaplan-Meier Survival by Era(Transplants: January 1982 – June 2011) All p-values significant at p < 0.001 except 2000-2004 vs. 2005-6/2011 (p=0.3658) 2013 JHLT. 2013 Oct; 32(10): 979-988

  32. Pediatric Heart TransplantsConditional Kaplan-Meier Survival for Recent Era(Transplants: January 2000 – June 2011) All pair-wise comparisons with 11-17 were significant at <0.001. No other pair-wise comparisons were significant at <0.05 2013 JHLT. 2013 Oct; 32(10): 979-988

  33. Pediatric Heart TransplantsKaplan-Meier Survival by EraAge: < 1 Year (Transplants: January 1982 – June 2011) All pair-wise comparisons were significant at <0.05 except 1982-1989 vs. 1990-1999 and 2000-2004 vs. 2005-6/2011 Median survival (years): 1982-1989=10.8; 1990-1999=18.3; 2000-2004=NA; 2005-6/2011=NA 2013 JHLT. 2013 Oct; 32(10): 979-988

  34. Pediatric Heart TransplantsKaplan-Meier Survival by EraAge: 1-5 Years (Transplants: January 1982 – June 2011) All p-values significant at < 0.02 except 2000-2004 vs. 2005-6/2011 (p=0.8360) Median survival (years): 1982-1989=8.6; 1990-1999=15.3; 2000-2004=NA; 2005-6/2011=NA 2013 JHLT. 2013 Oct; 32(10): 979-988

  35. Pediatric Heart TransplantsKaplan-Meier Survival by EraAge: 6-10 Years (Transplants: January 1982 – June 2011) All p-values significant at < 0.05 except 1982-1989 vs. 1990-1999 and 2000-2004 vs. 2005-6/2011 Median survival (years): 1982-1989=9.4; 1990-1999=12.9; 2000-2004=NA; 2005-6/2011=NA 2013 JHLT. 2013 Oct; 32(10): 979-988

  36. Pediatric Heart TransplantsKaplan-Meier Survival by EraAge: 11-17 Years (Transplants: January 1982 – June 2011) All pair-wise comparisons with 1982-1989 were significant at <0.05. 1990-1999 vs. 2000-2004 p=0.0110 No other pair-wise comparisons were significant at < 0.05 Median survival (years): 1982-1989=9.3; 1990-1999=12.1; 2000-2004=NA; 2005-6/2011=NA 2013 JHLT. 2013 Oct; 32(10): 979-988

  37. Pediatric Heart TransplantsKaplan-Meier Survival by Recipient Gender(Transplants: January 2000 – June 2011) p = 0.1772 2013 JHLT. 2013 Oct; 32(10): 979-988

  38. Pediatric Heart TransplantsKaplan-Meier Survival by Donor/Recipient Gender(Transplants: January 2000 – June 2011) No pair-wise comparisons were significant at < 0.05 2013 JHLT. 2013 Oct; 32(10): 979-988

  39. Pediatric Heart TransplantsKaplan-Meier Survival by DiagnosisAge: < 1 Year (Transplants: January 2000 – June 2011) p-value = 0.0004 2013 JHLT. 2013 Oct; 32(10): 979-988

  40. Pediatric Heart TransplantsKaplan-Meier Survival by DiagnosisAge: 1-5 Years (Transplants: January 2000 – June 2011) Congenital vs. Cardiomyopathy: p < 0.0001 Congenital vs. Retransplant: p = 0.6022 Cardiomyopathy vs. Retransplant: p = 0.0079 2013 JHLT. 2013 Oct; 32(10): 979-988

  41. Pediatric Heart TransplantsKaplan-Meier Survival by DiagnosisAge: 6-10 Years (Transplants: January 2000 – June 2011) Congenital vs. Cardiomyopathy: p = 0.0177 Congenital vs. Retransplant: p = 0.8384 Cardiomyopathy vs. Retransplant: p = 0.0454 2013 JHLT. 2013 Oct; 32(10): 979-988

  42. Pediatric Heart TransplantsKaplan-Meier Survival by DiagnosisAge: 11-17 Years(Transplants: January 2000 – June 2011) Congenital vs. Cardiomyopathy: p = 0.0010 Congenital vs. Retransplant: p = 0.3151 Cardiomyopathy vs. Retransplant: p<0.0001 2013 JHLT. 2013 Oct; 32(10): 979-988

  43. Pediatric Heart TransplantsKaplan-Meier Patient vs. Graft Survival (Transplants: 1/2000-6/2011)Average Center Volume: 1-4 Transplants per Year p = 0.1647 2013 JHLT. 2013 Oct; 32(10): 979-988

  44. Pediatric Heart TransplantsKaplan-Meier Patient vs. Graft Survival (Transplants: 1/2000-6/2011)Average Center Volume: 5-9 Transplants per Year p = 0.0310 2013 JHLT. 2013 Oct; 32(10): 979-988

  45. Pediatric Heart TransplantsKaplan-Meier Patient vs. Graft Survival (Transplants: 1/2000-6/2011)Average Center Volume: 10+ Transplants per Year p = 0.0076 2013 JHLT. 2013 Oct; 32(10): 979-988

  46. Pediatric Heart TransplantsKaplan-Meier Patient vs. Graft Survival (Transplants: 1/2000-6/2011)All Center Volumes p = 0.0003 2013 JHLT. 2013 Oct; 32(10): 979-988

  47. Pediatric Heart TransplantsKaplan-Meier Survival by Mechanical Circulatory Support Usage* (Transplants: January 2000 – June 2011) All pair-wise comparisons were significant at p < 0.001 except No ECMO/VAD/TAH vs. VAD or TAH, no ECMO 2013 * LVAD, RVAD, TAH, ECMO JHLT. 2013 Oct; 32(10): 979-988

  48. Pediatric Heart TransplantsFunctional Status of Surviving Recipients (Follow-ups: March 2005 – June 2012) 2013 JHLT. 2013 Oct; 32(10): 979-988

  49. Pediatric Heart TransplantsRehospitalization Post-transplant of Surviving Recipients (Follow-ups: January 2000 – June 2012) 2013 JHLT. 2013 Oct; 32(10): 979-988

  50. Induction and Maintenance Immunosuppression 2013 JHLT. 2013 Oct; 32(10): 979-988